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Graymatter
Graymatter

Graymatter

Regular price $44.99

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What is Gray Matter?

Gray Matter is an expert-formulated nootropic using cutting-edge science to create an energy and productivity-enhancing supplement like no other.*


The collection of research-backed compounds contained in Gray Matter help provide smooth clean energy and dialed-in focus with no jitters and no crash.* 


Not only does Gray Matter contain ingredients that support enhanced mental acuity and productivity, it also contains nutrients that foster neurotransmission and neuroprotection.* 


Collectively, this makes Gray Matter the go-to nootropic supplement for those seeking optimal cognitive performance on all levels -- attention, memory, focus, vigilance, and reaction time.*

Ingredients

L-Tyrosine (1g)

L-Tyrosine is a nonessential amino acid that fuels the biosynthesis of several highly important neurotransmitters, including dopamine and norepinephrine (noradrenaline).*[1]


Dopamine is most commonly thought of as the “reward” molecule, but the neurotransmitter also plays key roles in mood, motivation, motor control, and decision making.*


High levels of stress (such as that induced by extensive bouts of intense physical activity) can deplete levels of dopamine in the body, leading to poor mood, increased feelings of fatigue, and decrements in mental and physical performance.*[2]


Tyrosine supplementation may help to prevent this decrease in dopamine levels by supplying additional “raw materials” used to synthesize these important neurotransmitters, support mood, motivation, and focus.*

Organic Lion’s Mane Extract (500mg)

Lion’s Mane (Hericium erinaceus) is an edible mushroom used extensively in traditional Eastern Medicine for its healing properties.*[3,4,5] 


The mushroom rife with bioactive compounds such as erinacines, erinacea lactones, glycoproteins, hericerins, and polysaccharides (beta-glucans).*[6] 



Among the long list of benefits attributed to Lion’s Mane include[6,7]:

  • Anti-aging*
  • Anti-fatigue*
  • Antioxidant*
  • Improved cognitive function*
  • Neuroprotective*
  • Hepatoprotective*
  • Anti-Anxiety relief*
  • Anti-Inflammatory*
  • Immune system support*


Most pertinent to its inclusion in Gray Matter, Lion’s Mane consumption has also been noted to increase Nerve Growth Factor (NGF) in the brain.*


Nerve growth factor is a protein that’s vital to the function and survival of nerve cells.*[5,10] 


Additionally, Lion’s Mane has also been noted to promote cognitive function, memory and recall by promoting neuronal growth, reducing inflammation, and supporting overall brain health.*[5,8,9]

Pomegranate Juice Powder (350mg)

Memory loss and forgetfulness are one of the many unwanted side effects of aging.*


It’s believed that these effects are induced, at least partly, by changes in oxidative stress and inflammation.*[11]


As a result, researchers have begun investigating various foods and nutrients with anti-inflammatory and antioxidant properties to support cognitive function and brain health.*


One such food that has received attention is pomegranate.*


Pomegranate juice is rich in ellagitannin polyphenols, which have both antioxidant and anti-inflammatory properties.*[11]


These ellagitannins may reduce oxidative stress and inflammation, and thus may maintain brain health during aging.*


Unlike other antioxidants compounds which have poor bioavailability, the polyphenols contained in pomegranate (and their metabolites) are readily absorbed and may remain present in the body for up to 48 hours.*[29]


Furthermore, the gut breaks down ellagitannin into urolithin, which has been noted to inhibit neuroinflammation and confer neuroprotective effects against Alzheimer's disease.*[30,31]


Additional research indicates that pomegranate juice supplementation may improve memory performance and alter brain neural activity.*[12]


Finally, pomegranate juice may also benefit levels of “the learning neurotransmitter” acetylcholine as research indicates that one of the mechanisms by which pomegranate juice confers cognitive benefits is through inhibition of cholinesterase.*[13]

Natural Caffeine from Green Tea (200mg)

Caffeine is a central nervous stimulant that is a staple part of most people’s days, typically in the form of coffee, tea, pre workout supplements (like Mega Pre Black) or energy drinks (such as EAA Max Energy).*

Aside from the increase in energy, mood, and motivation caffeine provides, it’s also been noted to be a valuable cognitive boosting nutrient as well.*

The mechanisms by which caffeine exerts its effects are numerous, but the primary two are antagonism of adenosine receptors and stimulation of dopamine receptors in the brain.*

Adenosine is a calming neurotransmitter in the brain that fosters feelings of lethargy and fatigue.*

Since caffeine is structurally similar to adenosine, it can bind to adenosine receptors, thereby preventing adenosine from binding, leading to increased feelings of wakefulness and alertness.*

Regarding dopamine, caffeine not only stimulates dopamine release in the brain, but it also upregulates dopamine receptor availability and affinity.*[14,15] 

Gray Matter contains 200mg of natural caffeine per full (2-scoop) serving. 

This dose has been studied multiple times and shown to boost attention, improve reaction time and vigilance, heighten mood, and reduce fatigue.*[16,17,18,19,20]

TeaCrine® 40% (125mg)

Theacrine (1,3,7,9-tetramethyluric acid) is a “chemical cousin” of caffeine found in Kucha tea, Cupuacu, and Coffea robusta.*

TeaCrine is a patented form of nutrient supplying 40% theacrine by mass.*

Since TeaCrine is structurally similar to caffeine, it operates in the body similar to caffeine (adenosine antagonism and dopamine release) and confers many of the same effects as caffeine (increased wakefulness, greater feelings of energy, etc.)*


However, there are a few notable differences between the two.*


For starters, caffeine has a much faster onset of action than TeaCrine, meaning it “hits” harder and faster.*


However, the effects of caffeine are also rather short-lived.*


TeaCrine is “slower out of the gate” than caffeine as it takes 90-120 minutes to really “hit”, but those effects are longer-lasting, and smoother-feeling that caffeine.*


By combining caffeine with TeaCrine, you get the best of both worlds (quick-hitting energy with staying power).*


Moreover, TeaCrine does not come with habituation or tolerance build up that caffeine does. And, TeaCrine also doesn’t impact cardiovascular functions or sleep in the way that caffeine can.*


And, combining the two may also help to avoid the notorious “crash” that comes with caffeine usage.


Several studies have been conducted assessing the combination of caffeine and TeaCrine and found the dynamic duo may[21,22,23,24]:*

  • Enhance mental and physical performance better than caffeine alone*
  • Boost mood, focus, and psychometrics more than caffeine*
  • Boost energy levels for longer than caffeine alone*

Keto BHB Complex (4g)

Keto BHB complex supplies 4 grams of goBHB™ (exogenous ketone salts) from a mix of:

  • Sodium-BHB
  • Calcium-BHB
  • Magnesium-BHB

Ketone bodies (including BHB -- beta-hydroxybutyrate) have received increasing amounts of attention in recent years, largely due to the surge in popularity of all things keto.*

But, there is some “bite” to the “bark” surrounding ketones.*

For starters, ketones can serve as the main alternative fuel source for brain cells.*[25]

Aging as well as certain neurological disorders (such as Alzheimer’s) reduce the brain’s ability to metabolize glucose for energy.*

Ketones represent an efficient alternative fuel for both the normal and the injured brain.*[32]

Additionally, ketones (namely BHB) can stimulate mitochondrial biogenesis via the upregulation of genes encoding energy metabolism and mitochondrial enzymes.*[33]

They may also increase cerebral blood flow, which delivers more oxygen and nutrients to brain cells, supporting cognitive function.*[34]

Moreover, ketones have also been shown to up-regulate the production of an important protein called brain-derived neurotrophic factor (BDNF), which supports the health of existing neurons and helps grow new ones.*[26,27]

BDNF also helps increase the number of connections between synapses, which promotes long-term cognitive health and function.*

Finally, ketones have also been noted to possess neuroprotective effects.*[28]

 Disclaimer: 

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.

References

  1. Young SN. L-tyrosine to alleviate the effects of stress?. J Psychiatry Neurosci. 2007;32(3):224.
  2. Selasi Attipoe, Stacey A. Zeno, Courtney Lee, Cindy Crawford, Raheleh Khorsan, Avi R. Walter, Patricia A. Deuster, Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature, Military Medicine, Volume 180, Issue 7, July 2015, Pages 754–765, https://doi.org/10.7205/MILMED-D-14-00594
  3. Jiang S, Wang S, Sun Y, Zhang Q. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals. Appl Microbiol Biotechnol. 2014;98(18):7661-7670. doi:10.1007/s00253-014-5955-5. https://www.ncbi.nlm.nih.gov/pubmed/25070597
  4. Khan MA, Tania M, Liu R, Rahman MM. Hericium erinaceus: an edible mushroom with medicinal values. J Complement Integr Med. 2013;10. doi:10.1515/jcim-2013-0001. https://www.ncbi.nlm.nih.gov/pubmed/23735479
  5. Brandalise F, Cesaroni V, Gregori A, et al. Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice. Evidence-based Complementary and Alternative Medicine : eCAM. 2017;2017:3864340. doi:10.1155/2017/3864340. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237458/
  6. He X, Wang X, Fang J, et al. Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion’s Mane) mushroom: A review. Int J Biol Macromol. 2017;97:228-237. doi:10.1016/j.ijbiomac.2017.01.040. https://www.ncbi.nlm.nih.gov/pubmed/28087447
  7. Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J Agric Food Chem. 2015;63(32):7108-7123. doi:10.1021/acs.jafc.5b02914. http://pubs.acs.org/doi/abs/10.1021/acs.jafc.5b02914
  8. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-372. doi:10.1002/ptr.2634. https://www.ncbi.nlm.nih.gov/pubmed/18844328
  9. Zhang J, An S, Hu W, et al. The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model. Prokai-Tatrai K, ed. International Journal of Molecular Sciences. 2016;17(11):1810. doi:10.3390/ijms17111810. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133811/
  10. Lai P-L, Naidu M, Sabaratnam V, et al. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-554. https://www.ncbi.nlm.nih.gov/pubmed/24266378
  11. Siddarth, P., Li, Z., Miller, K. J., Ercoli, L. M., Merril, D. A., Henning, S. M., … Small, G. W. (2019). Randomized placebo-controlled study of the memory effects of pomegranate juice in middle-aged and older adults. The American Journal of Clinical Nutrition. doi:10.1093/ajcn/nqz241 
  12. BookheimerSY,RennerBA,EkstromA,LiZ,HenningSM,BrownJA, Jones M, Moody T, Small GW. Pomegranate juice augments memory and fMRI activity in middle-aged and older adults with mild memory complaints. Evidence-Based Complementary and Alternative Medicine 2013. https://doi.org/10.1155/2013/946298
  13. Amri Z, Ghorbel A, Turki M, et al. Effect of pomegranate extracts on brain antioxidant markers and cholinesterase activity in high fat-high fructose diet induced obesity in rat model. BMC Complement Altern Med. 2017;17(1):339. Published 2017 Jun 27. doi:10.1186/s12906-017-1842-9
  14. Grgic, J., Trexler, E.T., Lazinica, B. et al. Effects of caffeine intake on muscle strength and power: a systematic review and meta-analysis. J Int Soc Sports Nutr 15, 11 (2018) doi:10.1186/s12970-018-0216-0
  15. Volkow ND, Wang G-J, Logan J, et al. Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. Translational Psychiatry. 2015;5(4):e549-. doi:10.1038/tp.2015.46.
  16. Spriet LL. Exercise and sport performance with low doses of caffeine. Sports Med. 2014;44 Suppl 2(Suppl 2):S175–S184. doi:10.1007/s40279-014-0257-8
  17. Lieberman, H.R., R.J.Wurtman, G.G.Emde, and I.L.G.Coviella 1987. The effects of caffeine and aspirin on mood and performance. J. Clin. Pharmacol. 7:315–320
  18. Swift, C.G., and B.Tiplady 1988. The effects of age on the response to caffeine. Psychopharmacology 94:29–31
  19. Brunyé T.T. et al. (2010) Caffeine modulates attention network function.Brain Cogn, 72:181-8.
  20. McLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016). A review of caffeine’s effects on cognitive, physical and occupational performance. Neuroscience and Biobehavioral Reviews, 71, 294–312. https://doi.org/10.1016/j.neubiorev.2016.09.001
  21. Taylor L, Mumford P, Roberts M, et al. Safety of TeaCrine®®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. J Int Soc Sports Nutr. 2016;13(1):1-14. doi:10.1186/s12970-016-0113-3.
  22. He H, Ma D, Crone LB, et al. Assessment of the Drug-Drug Interaction Potential Between Theacrine and Caffeine  in Humans. J Caffeine Res. 2017;7(3):95-102. doi:10.1089/jcr.2017.0006.
  23. Wang Y, Yang X, Zheng X, Li J, Ye C, Song X. Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities. Fitoterapia. 2010;81(6):627-631. doi:https://doi.org/10.1016/j.fitote.2010.03.008.
  24. Kuhman DJ, Joyner KJ, Bloomer RJ. Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women. Nutrients. 2015;7(11):9618-32. Published 2015 Nov 19. doi:10.3390/nu7115484
  25. Cunnane SC, Courchesne-Loyer A, Vandenberghe C, et al. Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease. Front Mol Neurosci. 2016;9:53. Published 2016 Jul 8. doi:10.3389/fnmol.2016.00053
  26. Sleiman SF, Henry J, Al-Haddad R, et al. Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. Elife. 2016;5:e15092. Published 2016 Jun 2. doi:10.7554/eLife.15092
  27. Kim, S. W., Marosi, K., & Mattson, M. (2017). Ketone beta-hydroxybutyrate up-regulates BDNF expression through NF-κB as an adaptive response against ROS, which may improve neuronal bioenergetics and enhance neuroprotection (P3.090). Neurology, 88(16 Supplement), P3.090. Retrieved from http://n.neurology.org/content/88/16_Supplement/P3.090.abstract
  28. Yang H, Shan W, Zhu F, Wu J, Wang Q. Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms. Front Neurol. 2019;10:585. Published 2019 Jun 12. doi:10.3389/fneur.2019.00585
  29. Seeram NP et al. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J Nutr. 2006 Oct. 136(10): 2481-2485. doi: 10.1093/jn/136.10.2481
  30. Yuan, T., Ma, H., Liu, W., Niesen, D. B., Shah, N., Crews, R., … Seeram, N. P. (2016). Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites. ACS Chemical Neuroscience, 7(1), 26–33. https://doi.org/10.1021/acschemneuro.5b00260
  31. DaSilva, N. A., Nahar, P. P., Ma, H., Eid, A., Wei, Z., Meschwitz, S., … Seeram, N. P. (2019). Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro. Nutritional Neuroscience, 22(3), 185–195. https://doi.org/10.1080/1028415X.2017.1360558
  32. Prins ML: Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab 2008, 28:1-16.
  33. Veech RL, Chance B, Kashiwaya Y, Lardy HA, Cahill GF, Jr: Ketone bodies, potential therapeutic uses. IUBMB Life 2001, 51:241-247
  34. Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen N, Holm S, Paulson OB: Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Physiol 1996, 270:E746-E751.

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