MEGA PRE
MEGA PRE
MEGA PRE
MEGA PRE
MEGA PRE
MEGA PRE
MEGA PRE
MEGA PRE
MEGA PRE
MEGA PRE
MEGA PRE
  • SKU: MEGAP-SMB
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MEGA PRE

$44.99
DESCRIPTION

 

What is Mega Pre?

Mega Pre is a revelation to the pre workout landscape, touting a robust formula packing 8 research-backed ingredients. Each serving of Mega Pre provides the essential components the mind and body need to perform at its best.*

Mega Pre Black also contains NO stimulants, making it incredibly versatile for those that are stimulant-sensitive or train late at night.*

Why No Stimulants?!

The simple truth of the matter is that stimulants and stimulant blends are often the cheapest components to pre-workout formulas. Rather than throw in a bunch of cheap stimulants and charge the customer an egregious amount of money, Primeval Labs has invested time, effort, and money to bring you the finest quality ingredients all at their clinically backed doses.*

On top of that, stimulants may act as vasoconstrictors (reducing the diameter of blood vessels), which goes against everything that Mega Pre is intended to do -- promote increased blood flow for greater performance, gains, and PUMPS.*

If you’re really hurting for some stims, we offer several stim-based options that can be stacked with Mega Pre or you can simply have a cup of coffee alongside your serving of Mega Pre!*

Mega Pre Ingredients

L-Citrulline (6g)

Mega Pre is designed to support vasodilation, promote blood flow, enhance your performance, and give massive muscle pumps. There’s no single better ingredient to start off a comprehensive pump-boosting pre workout formula than L-Citrulline!*
Simply put, L-Citrulline is one of the premier nitric oxide-boosting compounds around, and noted in research to be more effective than L-Arginine due to its superior bioavailability.[1] L-Citrulline is a powerful endogenous precursor of L-arginine, which is the primary substrate for NO synthase, allowing for greater N.O. production and vasodilation in the body. This translates to tremendous vascularity and PUMPS![1]*
L-Citrulline is also a beneficial ergogenic as several studies have shown that L-Citrulline enhances Vo2 kinetics, ATP production, endurance, athletic performance, and even lean body mass!*[2,3,4,5]

  • Involved in nitric oxide production and metabolism*
  • Increased nitric oxide production supports blood flow and nutrient delivery*
  • May help reduce fatigue via ammonia buffering*
  • Noted in human studies to improve VO2 kinetics, energy produciton, and exercise performance*

Betaine (3g)

Primeval Labs has included Betaine at a whopping 4g per full serving. Derived from choline, betaine is a must-have ingredient in any performance boosting pre workout. It has been clearly shown to increase strength and lean mass, similar to that of creatine, and been found to actually enhance endogenous creatine production, via methylation of the amino acid homocysteine.

To sum it up into tangible results, betaine increases your power, strength, overall performance, and muscle growth.*[6,7]

  • Support creatine production*
  • May enhance power and strength output*
  • Promote cellular hydration*

GlycerPump (2g)

Hydration is a crucial, yet underemphasized, component of performance. Even a little as a 2% drop in hydration levels can lead to increased fatigue, decreased performance, and reduced cognitive function. To support your hydration needs even in the most extreme training conditions, Primeval Labs includes GlycerPump.*

GlyerPump is a cutting-edge, stabile form of glycerol containing 65% pure glycerol by weight. You’ve probably seen other forms of glycerol in pre workouts before, but none like GlycerPump.* Unlike all other forms of glycerol, GlycerPump does not clump, yet it also offers superior mixability and flavoring ability too.*

  • Contains 65% glycerol by mass
  • Supports cellular hydration and muscle fullness*
  • May help reduce the onset of fatigue, thereby increasing stamina*

Choline Bitartrate (1g)

Ever feel disconnected or unfocused during your workout despite taking a bunch of caffeine, yohimbine, or other stimulant? Do you walk out of the gym beyond frustrated before your workout is even over due to not feeling connected?

What you’re missing (and what your pre workout is lacking) is some much needed focus.*

More specifically, the reason you’re not into your workout is due to an absent mind-muscle disconnection. This special connection enables you to feel each and every muscle fiber contract during your workout, allowing you to get the most from every single repetition.*

To heighten your focus and foster a firm mind-muscle connection, Primeval Labs includes a full 1g dose of choline bitartrate to support production of the “learning transmitter” acetylcholine, which promotes focus and solidifies the “mind-muscle connection.”*[10,11]

  • Combination of choline and tartaric acid*
  • Helps increase choline concentrations in the body*
  • Supports production of acetylcholine -- the “learning neurotransmitter” -- which aids focus and the mind-muscle connection*

L-Norvaline (300mg)

L-Norvaline is a derivative of the branched-chain amino acid Valine that supports cardiovascular function and blood flow. Seeing that optimizing muscular blood flow is preeminent in Mega Pre, it’s no surprise this ingredient is an automatic inclusion!*

Norvaline prolongs the nitric oxide boosting effects of L-Citrulline by inhibiting arginase activity in the body.[12] Reducing the activity arginase promotes unrestricted nitric oxide production, allowing for greater vasodilation and longer-lasting muscle pumps!*

  • Derivative of the BCAA L-Valine*
  • May inhibit arginase*
  • Synergizes with L-Citrulline to support long-lasting nitric oxide production*

VasoDrive-AP (254mg)

Angiotensin converting enzyme (ACE) is a devilish little enzyme in the body that causes vasoconstriction. Left unchecked, ACE reduces blood flow, impacting nutrient and oxygen delivery to working muscles, starving them of the essential nutrient they need to perform at a high level.*

Enter VasoDrive-AP, a groundbreaking ingredient that inhibits ACE activity in the body. Vaso-Drive is a patented, proprietary ingredient derived from casein comprised of two tripeptides -- Valyl-Prolyl-Proline (VPP) and Isoleucyl-Prolyl-Proline(IPP).*

Studies using the tripeptides demonstrate the novel ingredient promotes healthy blood pressure, arterial elasticity and blood flow, and protects muscle cells against free radical-related dysfunction.[6,7,8] Moreover, VasoDrive-AP may enhance blood flow, insulin sensitivity, and athletic performance all via reducing ACE activity in the body.*[13,14,15]

  • Casein-derived tripeptide that has been documented to inhibit angiotensin-converting enzyme*
  • Through ACE inhibition, VasoDrive-AP supports increased blood flow and nutrient delivery*
  • Supports athletic performance*

ElevATP (150mg)

A proprietary combination of ancient peat and apple extracts, elevATP is a novel ingredient noted in research to improve ATP production and release in the body![8,9,17] On top of that, supplementing with elevATP also has been shown to increase 1-rep maximum squat and deadlift as well as vertical jump peak power and velocity.[18]

It’s also worth mentioning that elevATP may improve your muscle pumps during training, as ATP encourages vasodilation by way of increasing nitric oxide.[19]

  • Combination of ancient peat and apple extracts*
  • Shown to improve ATP production in the body*
  • May improve performance in squat, deadlift and vertical jump*

Huperzine A (100mcg)

Huperzine is a powerful nootropic that serves to enhance the effects of Choline Bitartrate by inhibiting acetylcholinesterase, the enzyme that degrades acetylcholine.[16] Pairing Huperzine + Choline make for a long-lasting, highly effective nootropic duo that promotes sustained focus and a superior mind-muscle connection.*

  • Selective inhibitor of acetylcholinesterase (the enzyme that degrades acetylcholine)*
  • Promotes increased concentrations of acetylcholine*
  • Aids focus, memory, and learning*

Disclaimer:

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.

References

  1. Curis E., et. al; “Citrulline and the gut;”; Current Opinion in Clinical Nutrition and Metabolic Care; September 2007
  2. Bailey SJ, Blackwell JR, Lord T, Vanhatalo A, Winyard PG, Jones AM. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol (1985). 2015 Aug 15;119(4):385-95
  3. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010 May;24(5):1215-22.
  4. Suzuki T, Morita M, Kobayashi Y, Kamimura A. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study. J Int Soc Sports Nutr. 2016;13(1):6. doi:10.1186/s12970-016-0117-z.
  5. Gonzales JU, Raymond A, Ashley J, Kim Y. Does l-citrulline supplementation improve exercise blood flow in older adults? Exp Physiol. September 2017. doi:10.1113/EP086587.
  6. Lee EC, Maresh CM, Kraemer WJ, et al. Ergogenic effects of betaine supplementation on strength and power performance. Journal of the International Society of Sports Nutrition. 2010;7:27. doi:10.1186/1550-2783-7-27.
  7. Trepanowski JF, Farney TM, McCarthy CG, Schilling BK, Craig SA, Bloomer RJ. The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men. J Strength Cond Res. 2011;25. doi:10.1519/JSC.0b013e318217d48d.
  8. Reyes T, Shu C, Argumedo R, Nemzer B, Pietrzkowski Z. The Effect of ElevATPTMon Whole Blood ATP Levels: A Single Dose, Cross over Clinical Study. Vol 1.; 2014.
  9. Joy J, Vogel R, Moon J, Falcone P, Mosman M, P. Kim M. Twelve Weeks Supplementation with an Extended-Release Caffeine and ATP-Enhancing Supplement May Improve Body Composition without Affecting Hematology in Resistance-Trained Men. Vol 13.; 2016. doi:10.1186/s12970-016-0136-9.
  10. Wallace JMW, McCormack JM, McNulty H, et al. Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. Br J Nutr. 2012;108(7):1264-1271. doi:10.1017/S000711451100674X. https://www.ncbi.nlm.nih.gov/pubmed/22172554
  11. Cohen BM, Renshaw PF, Stoll AL, Wurtman RJ, Yurgelun-Todd D, Babb SM. Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study. JAMA. 1995;274(11):902-907. https://www.ncbi.nlm.nih.gov/pubmed/7674505
  12. El-Bassossy HM, El-Fawal R, Fahmy A. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. Vascul Pharmacol. 2012;57(5-6):194-200. doi:10.1016/j.vph.2012.01.001.
  13. FitzGerald RJ, Meisel H. Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Br J Nutr. 2000;84 Suppl 1:S33-37.
  14. Hirota T, Ohki K, Kawagishi R, et al. Casein hydrolysate containing the antihypertensive tripeptides Val-Pro-Pro and Ile-Pro-Pro improves vascular endothelial function independent of blood pressure-lowering effects: contribution of the inhibitory action of angiotensin-converting enzyme. Hypertension research : official journal of the Japanese Society of Hypertension. 2007;30(6):489-496.
  15. Fekete ÁA, Givens DI, Lovegrove JA. Casein-Derived Lactotripeptides Reduce Systolic and Diastolic Blood Pressure in a Meta-Analysis of Randomised Clinical Trials. Nutrients. 2015;7(1):659-681.
  16. Zhao, Q; Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; 2002
  17. Joy J, Falcone P, Vogel R, Mosman M, P Kim M, Moon J. Supplementation with a Proprietary Blend of Ancient Peat and Apple Extract May Improve Body Composition without Affecting Hematology in Resistance-Trained Men. Vol 40.; 2015. doi:10.1139/apnm-2015-0241.
  18. Joy JM et al., “Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men,” BMC Complementary and Alternative Medicine, vol. 16, no. 1 (July 2016): 224;
  19. van Ginneken EE, Meijer P, Verkaik N, Smits P, Rongen GA. ATP-induced vasodilation in human skeletal muscle. Br J Pharmacol. 2004;141(5):842–850. doi:10.1038/sj.bjp.0705589
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