PYRETIC
PYRETIC
PYRETIC
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  • SKU: PYRE-TIC

PYRETIC

$49.99
DESCRIPTION

What is Pyretic?

Pyretic is our take on the stimulant-free fat loss support formula that uses only natural ingredients to support fat burning, metabolism, and appetite suppression.*

By using this multifaceted approach to weight loss, Pyretic stands apart from other thermogenic fat burning supplements on the market.*

The best part is, there are absolutely no stimulants whatsoever!*

Maximizing fat loss and achieving a ripped physique demands consistency and effort at the gym and in the kitchen. Pyretic is not a "quick fix" fat loss pill like other brands claim, but when combined with a proper nutrition plan and training program, it may enhance results.*

Pyretic Ingredients

Choline Bitartrate

Choline is an essential nutrient required for optimal brain development as well as the formation of two highly important phospholipids that build cell membranes. It also provides the “backbone” for acetylcholine, a neurotransmitter that plays a key role in learning, memory, and muscle contraction.*

Beyond its ability to help support greater focus and learning, additional research indicates that supplementing with choline may help increases carnitine retention in the body.[1]*

Why is this noteworthy?

Well, carnitine is a compound in the body that facilitates the transport of fatty acids into the mitochondria so that they can be oxidized (“burned”) for energy. Deficiencies in carnitine levels may impair energy production and fat burning.*

Therefore, supplementing with choline may help maintain higher levels of carnitine, promoting greater fat mobilization and oxidation.[2,3,4]*

KSM-66®

There’s no other way to say it, dieting is stressful to the body, both mentally and physically. Not only do you have to willingly deprive yourself of food, but you also have to increase energy output (as weight loss dictates that energy intake be less than energy output).

This state of heightened stress leads to elevated cortisol levels, which can impair recovery, mood, cognitive function, and performance (again, both mentally and physically).

Ashwagandha (Withania Somnifera or Indian Ginseng) is an adaptogen that helps improve the body’s ability to perceive, interact and recover from stress, thereby promoting balance in the body.* 

KSM-66® is a high-quality ashwagandha extract noted in multiple clinical trials to help reduce stress, improve memory and cognition, enhance sports performance, boost sexual performance, and support weight management.*[5,6,7,8]

Gymnema Sylvestre (300mg)

Gymnema sylvestre is a common supplement for those seeking to support blood glucose regulation and insulin levels. The reason for this is that research demonstrates that consistent administration of gymnema may help lower serum glucose levels and HbA1c.[9,10]*

 

Additional studies have found that gymnema may enhances insulin function. And, as you likely realize, better insulin functioning supports greater nutrient partitioning as well as more stable blood sugar (and therefore, energy) levels.*

A comprehensive review of gymnema sylvestre even noted that supplementation may help improve leptin levels, body weight and BMI (body mass index).[11]*

Beyond its anti-diabetic properties, gymnema has also been found to possess antimicrobial, antihypercholesterolemic, and hepatoprotective activities[9,12]*

Coleus Forskohlii (10% forskolin)

When it comes to stimulant-free fat burning supplements, Coleus Forskohlii (Forskolin) is about as good as it gets!* 

Forskolin promotes weight loss by increasing cAMP (cyclic adenosine monophosphate) levels in the body.[11] cAMP is a derivative of ATP that serves as a chemical messenger involved in numerous biological processes.*


Activation of cAMP ignites lipolysis (the breakdown of fat stores in the body) while also inhibiting fat synthesis in the body.[13,14] In other words, forskolin may help liberate stored fatty acids to be oxidized for energy and limit fat synthesis.*

Additional research indicates that forskolin may reduce appetite and help preserve lean muscle mass while dieting.*[15,16]

InnoSlim®

InnoSlim® is a patented extract composed of highly purified and fractionated

 from Panax notoginseng and Astragalus membranaceus demonstrated to support weight loss via the Adiponectin-AMPK-HIF-1-GLUT4 pathway, which may help reduce blood glucose and fat accumulation.*

In case you weren’t aware, AMPK is an enzyme that serves as the body’s “master energy regulator. As such, it stimulates fatty acid oxidation (fat burning) in liver and skeletal muscle, ketogenesis, and glucose uptake into skeletal muscle.

Studies have found that InnoSlim® decreases glucose absorption in the intestine by reducing the glucose transporter SGLT1. It’s also been noted to upregulate glucose absorption in muscle and fat cells by enhancing the activity of glucose transport protein GLUT4.[18,19]*

Other studies find that InnoSlim® administration can enhance levels of adiponectin -- a protein that regulates glucose levels and fatty acid oxidation. Higher concentrations of adiponectin lead to reductions in fat cell formation and greater energy expenditure.*[18,19]

Furthermore, since InnoSlim® reduces SGLT1 in the intestine, it may also help reduce calorie consumption. Finally, InnoSlim® may also help suppress appetite by decreasing blood glucose levels and increasing insulin activity.*[18,19]

GBB

Gamma-butyrobetaine (GBB) is a precursor to L-Carnitine noted to increase the production of L-Carnitine by your body, even more effectively than supplemental forms of carnitine.[20,21] 

As stated above, carnitine plays a key role in energy metabolism as it serves as the “shuttle” for fatty acids to enter the mitochondria and be oxidized for energy. By increasing carnitine production in the body, GBB not only supports fat burning but may also enhance exercise performance via its ability to aid energy production.*

Be aware that GBB is known to have a fairly potent thermogenic effect in the body, so expect to feel the heat.*

Paradoxine®

Paradoxine (Aframomum Melegueta or Grains of Paradise) is a pungent spice with a long history of use in traditional medicine. 

Modern studies have identified it as a potential stimulant-free fat loss support agent due to its ability to increase energy expenditure and mobilize fat from brown adipose tissue (BAT thermogenesis), which enhances calorie burning and weight loss.*[22,23,24]

Similar to GBB, Paradoxine is known to pack a thermogenic punch -- there’s a reason the product is called Pyretic, after all.*

Suggested Use

Consume 3 capsules in the morning and 3 capsules in the evening for a total of 6 capsules daily.

Disclaimer:

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.

      REFERENCES

      References

      1. Elsawy G, Abdelrahman O, Hamza A. Effect of Choline Supplementation on Rapid Weight Loss and Biochemical Variables Among Female Taekwondo and Judo Athletes. Journal of Human Kinetics. 2014;40:77-82. doi:10.2478/hukin-2014-0009. 
      2. Dodson WL, Sachan DS. Choline supplementation reduces urinary carnitine excretion in humans. Am J Clin Nutr. 1996;63(6):904-910.
      3. Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr. 2003;133(1):84-89. 
      4. Daily JW 3rd, Sachan DS. Choline supplementation alters carnitine homeostasis in humans and guinea pigs. J Nutr. 1995;125(7):1938-1944. 
      5. Choudhary, D., Bhattacharyya, S., & Joshi, K. Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. (2017). Journal of evidence-based complementary & alternative medicine, 22(1), 96-106.
      6. Choudhary, D., Bhattacharyya, S., & Bose, S. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions. (2017). Journal of Dietary Supplements, 1-14. Chicago
      7. Chandrasekhar, K., Kapoor, J., & Anishetty, S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. (2012). Indian journal of psychological medicine, 34(3), 255.
      8. Choudhary, B., Shetty, A., & Langade, D. G. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. (2015). Ayu, 36(1), 63.
      9. Ulbricht, Catherine, et al. "An Evidence-Based Systematic Review of Gymnema (Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration." Journal of Dietary Supplements, vol. 8, no. 3, 2011, pp. 311-330.
      10. Baskaran, K., et al. "Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients." Journal of Ethnopharmacology, vol. 30, no. 3, 1990, pp. 295-305.
      11. Kanetkar P, Singhal R, Kamat M. Gymnema sylvestre: A Memoir. J Clin Biochem Nutr. 2007;41(2):77-81.
      12. Zuñiga, Laura Y., et al. "Effect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion." Journal of Medicinal Food, vol. 20, no. 8, 2017, pp. 750-754.
      13. Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res 1981;7:201-24. 
      14. Allen DO, Ahmed B, et al. Relationships between cyclic AMP levels and lipolysis in fat cells after isoproterenol and forskolin. J Pharmacol Exp Ther. 1986;238:659-64.
      15. Henderson S, Magu B, Rasmussen C, et al. Effects of Coleus Forskohlii Supplementation on Body Composition and Hematological Profiles in Mildly Overweight Women. Journal of the International Society of Sports Nutrition. 2005;2(2):54-62. doi:10.1186/1550-2783-2-2-54. 
      16. Godard, M. P., Johnson, B. A. and Richmond, S. R. (2005), Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men. Obesity Research, 13: 1335–1343. doi:10.1038/oby.2005.162
      17. Bagchi D, Preuss HG. Obesity: Epidemiology, Pathophysiology, and Prevention. Edition, S. (2012).
      18. https://nulivscience.com/application/files/5215/5500/9632/InnoSlim_Overview_1.pdf
      19. https://nulivscience.com/application/files/1115/5500/9183/InnoSlim_Product_Facts-sheet.pdf
      20. Charles J. Rebouche, E. Peter Bosch, Catherine A. Chenard, Kay J. Schabold, Steven E. Nelson; “Utilization of Dietary Precursors for Carnitine Synthesis in Human Adults”; The Journal of Nutrition, Volume 119, Issue 12, 1 December 1989, Pages 1907–1913
      21. Ann Louise Olson, Charles J. Rebouche; “γ-Butyrobetaine Hydroxylase Activity is Not Rate Limiting for Carnitine Biosynthesis in the Human Infant”; The Journal of Nutrition, Volume 117, Issue 6, 1 June 1987, Pages 1024–1031
      22. Sugita, J., Yoneshiro, T., et al; “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738; 
      23. Sugita J, Yoneshiro T, et al; “Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans”; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27 
      24. Momoe Iwami, Fatma A. Mahmoud, et al; “Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats”; Autonomic Neuroscience: Basic and Clinical; 161 (2011); 63–67
        INSTAGRAM
        †These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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