Insulin is the hormone that governs how cells absorb, utilize, and store nutrients and energy. On top of that, it also directly impacts certain genetic processes involving muscle protein synthesis.*
The catch with insulin is that it can either work for you or against you, based on your genetics.*
When you eat carbohydrates, your pancreas releases insulin, which then transports the carbs into fat and muscle tissue. The genetically gifted individuals of the world have higher insulin sensitivity in their muscle cells and lower insulin sensitivity in the fat cells. This allows them to crush as many carbs as they want while storing very little fat and building a lot of muscle mass.*
The rest of us are stuck with either very average to very poor insulin sensitivity, making it far more likely to accumulate a good bit of fat in addition to muscle when pounding carbs. This has led to the demonization of carbs and a general avoidance of the tasty macro by the vast majority of the population, including high-level athletes!*
Truth be told, you NEED carbohydrates as they are the preferred form of fuel for your muscles and the most powerful. Liken carbs to premium gasoline in a sports car, and you begin to get a better understanding of just how useful they can be for taking performance in the gym to a whole new level.*
This puts athletes with not so great genetics in a pickle.*
Do they forego carbs and sacrifice performance, or do they embrace carbs and the inevitable fat gain that comes with it?!
Primalog is an all-natural glucose disposal agent and nutrient partitioning aid that supports carbohydrate utilization, athletic performance, muscle growth, and body composition.*
Primalog is ideal to use pre-workout, as it supports carbohydrate uptake and utilization by skeletal muscles, promoting greater athletic performance during training.*
It’s also great to use on those weekly cheat meals when you want to crush some serious carb-heavy food, but want to limit associated fat gain that comes with typical high-carb meals.*
Gymnema Sylvestre (1g)
Gymnema Sylvestre is a powerful herb native to the central and southern forests of India and Sri Lanka. Also known as cowplant, gymnema has been extensively researched for its ability to aid insulin function.*
Better insulin function promotes stable blood sugar levels, and helps shuttle those pre workout carbs into skeletal muscles where they can get to work supporting training performance and energy production.*
A comprehensive review of gymnema sylvestre noted it also may reduce plasma glucose, leptin levels, body weight and even BMI (body mass index).*
- Southeast asian herb that supports insulin function*
- Studies show it may help reduce plasma glucose and leptin levels*
May help limit the accumulation of triglycerides in muscle and liver, and also decrease fatty acid accumulation in circulation*
Agmatine Sulfate (750mg)
A derivative of arginine, agmatine is an endogenous neurotransmitter and a commonly used ingredient in nitric oxide boosting pre workouts, but it may also serve to improve nutrient partitioning as well.*
Agmatine activates imidazoline receptors which have been noted to helps reduce blood glucose levels and is associated with an increase in beta-endorphins.*[3,4]
In case you weren’t aware, beta-endorphin can increase glucose uptake into muscle tissue, even when during periods of low physical activity.[5,6] Other research has shown that beta-endorphin may aid the pancreas with insulin secretion.*
- Derivative of arginine that stimulates imidazoline receptors and may help reduce blood glucose levels*
- Supports nutrient partitioning*
- Studies note it may help reduce pain associated with inflammation*
Bitter Melon 4:1 Extract (500mg)
Cultivated all over the world from the Caribbean to Africa and even Asia, bitter melon (Momordica Charantia) has been used over the centuries as a treatment for a number of different ailments and diseases including respiratory complications, stomach bugs, and even diabetes.*
Bitter melon contains three active compounds with anti-diabetic properties, including charantin, vicine, and an insulin-like compound called polypeptide-p. Research confirms that charantin does indeed have a blood glucose-lowering effect in the body, and some studies have even suggested it’s comparable to tolbutamide (a common antidiabetic prescription) for treating symptoms associated with diabetes.[9,10,42]*
Some other interesting research into bitter melon shows it may help suppress adipose tissue inflammation. Perhaps most noteworthy about this bitter-tasting veggie is that it has been shown to decrease glycogen formation in the liver (glycogenesis) while also increasing glucose uptake and utilization as well as serum protein levels.*
- Contains three compounds with anti-diabetic properties*
- Noted in research to help lower blood glucose*
- Supports glucose uptake and utilization*
Banaba Leaf Powder (300mg)
Banaba, a.k.a. Lagerstroemia, is an well-known plant, largely due to its antidiabetic properties.* The leaves of the banaba plant are rich in a compound known as corosolic acid, which has some pretty impressive research behind it.*
Corosolic acid is believed to induce GLUT4 translocation, which leads to increased insulin activity.[13,14] In case you weren’t aware, GLUT4 is the insulin-responsive glucose transporter gene in the body. Research has shown that a malfunctioning GLUT4 gene may cause insulin resistance in skeletal muscle as well as diabetes.*
Corosolic acid inhibits enzymatic activities of several diabetes-related non-receptor protein tyrosine phosphatases, including PTP1B, which can enhance insulin receptor B phosphorylation and make it a viable option for combatting symptoms associated with obesity and diabetes.* That’s not all though, corosolic acid also supports glycolysis and reduces gluconeogenesis. Some research has even shown it’s beneficial for weight loss too, via inhibition of pancreatic lipase enzyme (the enzyme responsible for fat absorption).*
Finally, Banaba also has research noting that it may enhance insulin sensitivity and glucose transport, allowing for superior glucose utilization during intense training.*[18,19,20]
- Plant rich in corosolic acid, a compound with anti-diabetic properties*
- Supports insulin function via GLUT4 translocation*
- May aid weight loss via inhibition of enzymes involved with fat absorption*
Berberine is an underrated herb that has been documented to offer a wide number of benefits, especially in regards to its anti-inflammatory and antidiabetic properties.*
The compound has been noted in research to enhance glucose uptake into skeletal muscle via AMPK activation.*[21,22]
Note: AMPK (5' adenosine monophosphate-activated protein kinase) is an enzyme that plays a key role in cellular energy balance, and activation of AMPK may increase mitochondrial biogenesis in skeletal muscle cells, reduce fat storage, and improve insulin sensitivity.*[23,24,25]
Interestingly enough, berberine also has some data noting it may be able to stimulate glucose uptake into muscle cells by itself even if the cell happens to be insulin resistant.*
- Supports glucose uptake into skeletal muscle via AMPK activation*
- Offers anti-inflammatory and anti-diabetic properties*
One nutrient you’ve probably never come across in any supplement is Cyanidin-3-Glucoside, or C3G for short, and it’s one of the main reasons Primalog stands apart from any other glucose disposal agent on the market.*
C3G is an anthocyanidin naturally-occurring in the dark-colored regions and skins of dark purple fruits, such as blueberries or blackberries. C3G has been documented to increase glucose uptake by increasing GLUT4 expression translocation. On top of that, this powerful antioxidant also has been noted to upregulate PPARγ activity, which may mimic some insulin-like actions.*
PPARγ is the most extensively researched gene for the treatment of type 2 diabetes, primarily because it’s the main metabolic regulator of organs and tissues. Increased PPARγ expression/activity has been shown to enhance insulin sensitivity and glucose uptake.*[29,30]
To top it off, C3G also can function as a powerful alpha-amylase inhibitor. Alpha-amylase is one of the salivary enzymes that aid starch digestion.*
- Antioxidant found in dark-colored fruits, such as blueberries*
- Noted in research to increase glucose uptake via GLUT4 translocation*
- C3G also has some data suggesting it may upregulate PPARγ activity*
Na-R-Alpha Lipoic Acid (100mg)
Alpha Lipoic Acid (ALA) is a fatty acid generated by the body and found in the mitochondria of every cell in your body. It’s an essential player in energy metabolism and also functions as a powerful antioxidant in the body. *
Na-R-ALA is an incredibly common supplement found in GDAs, and for good reason too! Research notes that it can reduce fasting blood sugar, suppress appetite, and increase energy expenditure.*[34,35]
This form of ALA binds the fatty acid to a sodium salt, making it incredibly soluble and highly bioavailable. It’s also more heat stable at higher temperatures compared to other forms of ALA, which is a good thing in case you leave your supplements in your gym bag in a hot car during the day!*
- Stabilized form of ALA formed from a combination of sodium salt and R-Lipoic Acid (RLA)*
- ALA functions as an important antioxidant in the body*
- Studies indicate it may support glucose disposal and appetite suppression*
Alpha Lipoic Acid (100mg)
Primalog contains an additional 100mg ALA to further support glucose disposal and metabolism. Combining the two forms provides a powerful duo of advanced glucose disposal agents that may regulate blood sugars, reduce appetite, and support a healthy body composition.*[36,37]
Chromium is a trace mineral essential to a number of important function in the body, such as stimulating cholesterol synthesis required for optimal brain function. It also plays a key role in insulin metabolism as well!*
Simply put, insulin requires chromium in order to function properly, without adequate chromium, insulin metabolism suffers and so does the uptake and utilization of glucose, amino acids, and fats. This means that protein synthesis is severely inhibited and all of your hopes of building muscle and losing fat go down the tube.*
Research has shown that individuals with type 2 diabetes have lower blood levels of chromium than those without the disease. Primalog contains chromium in the form of chromium nicotinate glycinate chelate as opposed to the well-known chromium picolinate. The reason for using this particular form is that the chromium contained in Primalog is bound to niacin, and research shows that it’s 18x more bioactive than other types of chromium. In fact, some animal studies show it’s absorbed and retained 600% more than chromium chloride and 300% more than the frequently used common chromium picolinate!*
- Trace mineral involved in numerous biological processes, including insulin metabolism*
- Research notes that individuals with Type 2 diabetes have lower chromium levels than individuals without the disease*
- May improve insulin sensitivity and glucose metabolism*
Consume 7 capsules 15-20 minutes prior to training (along with at least 50g carbohydrates). Primalog can also be dosed 15-20 minutes before your heaviest carb-containing meal of the day as well.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
Kanetkar P, Singhal R, Kamat M. Gymnema sylvestre: A Memoir. Journal of Clinical Biochemistry and Nutrition. 2007;41(2):77-81. doi:10.3164/jcbn.2007010.
Pothuraju, R., Sharma, R. K., Chagalamarri, J., Jangra, S. and Kumar Kavadi, P. (2014), A systematic review of Gymnema sylvestre in obesity and diabetes management. J. Sci. Food Agric., 94: 834–840. doi: 10.1002/jsfa.6458.
Chang C-H, Wu H-T, Cheng K-C, Lin H-J, Cheng J-T. Increase of beta-endorphin secretion by agmatine is induced by activation of imidazoline I(2A) receptors in adrenal gland of rats. Neurosci Lett. 2010;468(3):297-299. doi:10.1016/j.neulet.2009.11.018.
Hwang S-L, Liu I-M, Tzeng T-F, Cheng J-T. Activation of imidazoline receptors in adrenal gland to lower plasma glucose in streptozotocin-induced diabetic rats. Diabetologia. 2005;48(4):767-775. doi:10.1007/s00125-005-1698-2.
Khan S, Evans AAL, Hughes S, Smith ME. Beta-endorphin decreases fatigue and increases glucose uptake independently in normal and dystrophic mice. Muscle Nerve. 2005;31(4):481-486. doi:10.1002/mus.20286.
Cheng JT, Liu IM, Tzeng TF, Tsai CC, Lai TY. Plasma glucose-lowering effect of beta-endorphin in streptozotocin-induced diabetic rats. Horm Metab Res = Horm und Stoffwechselforsch = Horm Metab. 2002;34(10):570-576. doi:10.1055/s-2002-35418.
Curry DL, Bennett LL, Li CH. Stimulation of insulin secretion by beta-endorphins (1-27 & 1-31). Life Sci. 1987;40(21):2053-2058.
Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pacific Journal of Tropical Disease. 2013;3(2):93-102. doi:10.1016/S2222-1808(13)60052-3.
Pitipanapong J, Chitprasert S, Goto M, Jiratchariyakul W, Sasaki M, Shotipruk A. New approach for extraction of charantin from Momordica charantia with pressurized liquid extraction. Sep Purif Technol. 2007;52(3):416-422. doi:https://doi.org/10.1016/j.seppur.2005.11.037.
- Cousens G. There is a cure for diabetes: the tree of life 21 day program. California: North Atlantic Books; 2008. pp. 191–192
Bao B, Chen Y-G, Zhang L, et al. Momordica charantia (Bitter Melon) Reduces Obesity-Associated Macrophage and Mast Cell Infiltration as well as Inflammatory Cytokine Expression in Adipose Tissues. Fritz JH, ed. PLoS ONE. 2013;8(12):e84075. doi:10.1371/journal.pone.0084075.
Fernandes NP, Lagishetty CV, Panda VS, Naik SR. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complementary and Alternative Medicine. 2007;7:29. doi:10.1186/1472-6882-7-29.
Miura T, Itoh Y, Kaneko T, et al. Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice. Biol Pharm Bull. 2004;27(7):1103-1105.
Stenbit AE, Tsao T-S, Li J, et al. GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nat Med. 1997;3:1096. http://dx.doi.org/10.1038/nm1097-1096.
Pei Z, Liu G, Lubben TH, Szczepankiewicz BG. Inhibition of protein tyrosine phosphatase 1B as a potential treatment of diabetes and obesity. Curr Pharm Des. 2004;10(28):3481-3504.
Zhang Z-Y, Lee S-Y. PTP1B inhibitors as potential therapeutics in the treatment of Type 2 diabetes and obesity. Expert Opin Investig Drugs. 2003;12(2):223-233. doi:10.1517/13543718.104.22.168.
Yamada K, Hosokawa M, Fujimoto S, et al. Effect of corosolic acid on gluconeogenesis in rat liver. Diabetes Res Clin Pract. 2008;80(1):48-55. doi:https://doi.org/10.1016/j.diabres.2007.11.011.
Takagi S, et al; Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice . Biomed Res. (2010)
Miura T, Takagi S, Ishida T; Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid . Evid Based Complement Alternat Med. (2012)
Judy WV, et al; Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study . J Ethnopharmacol. (2003)
Yin J, Xing H, Ye J. Efficacy of Berberine in Patients with Type 2 Diabetes. Metabolism: clinical and experimental. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013.
Lin W, Huang X, Zhang L, Chen D, Wang D, Peng Q, et al. (2012) BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase. PLoS ONE7(8): e44570. https://doi.org/10.1371/journal.pone.0044570
Dong H, Wang N, Zhao L, Lu F. Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis. Evidence-based Complementary and Alternative Medicine : eCAM. 2012;2012:591654. doi:10.1155/2012/591654.
Godugu C, Patel AR, Doddapaneni R, Somagoni J, Singh M (2014) Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid. PLoS ONE 9(3): e89919. https://doi.org/10.1371/journal.pone.0089919.
Bustanji Y, Taha MO, Yousef A-M, Al-Bakri AG. Berberine potently inhibits protein tyrosine phosphatase 1B: investigation by docking simulation and experimental validation. J Enzyme Inhib Med Chem. 2006;21(2):163-171. doi:10.1080/14756360500533026.
Liu L-Z, Cheung SCK, Lan L-L, et al. Berberine modulates insulin signaling transduction in insulin-resistant cells. Mol Cell Endocrinol. 2010;317(1-2):148-153. doi:10.1016/j.mce.2009.12.027.
Scazzocchio B, Varì R, Filesi C, et al. Cyanidin-3-O-β-Glucoside and Protocatechuic Acid Exert Insulin-Like Effects by Upregulating PPARγ Activity in Human Omental Adipocytes. Diabetes. 2011;60(9):2234-2244. doi:10.2337/db10-1461.
Miyazaki Y, Mahankali A, Wajcberg E, Bajaj M, Mandarino LJ, DeFronzo RA. Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 2004;89:4312–4319
Seymour EM, Lewis SK, Urcuyo-Llanes DE, et al. Regular tart cherry intake alters abdominal adiposity, adipose gene transcription, and inflammation in obesity-prone rats fed a high fat diet. J Med Food 2009;12:935–942
Tsuda T, Ueno Y, Yoshikawa T, Kojo H, Osawa T. Microarray profiling of gene expression in human adipocytes in response to anthocyanins. Biochem Pharmacol 2006;71:1184–1197
Homoki JR, Nemes A, Fazekas E, et al. Anthocyanin composition, antioxidant efficiency, and alpha-amylase inhibitor activity of different Hungarian sour cherry varieties (Prunus cerasus L.). Food Chem. 2016;194:222-229. doi:10.1016/j.foodchem.2015.07.130.
Sales PM, Souza PM, Simeoni LA, Silveira D. alpha-Amylase inhibitors: a review of raw material and isolated compounds from plant source. J Pharm Pharm Sci. 2012;15(1):141-183.
Ansar H, Mazloom Z, Kazemi F, Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J. 2011;32(6):584-588.
Kim MS, et al; Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase . Nat Med. (2004)
Cheng PY, et al; Reciprocal effects of α-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats . Menopause. (2011)
Wang Y, et al; alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice . Metabolism. (2010)
Mohammadi V, Khorvash F, Feizi A, Askari G. The effect of alpha-lipoic acid supplementation on anthropometric indices and food intake in patients who experienced stroke: A randomized, double-blind, placebo-controlled clinical trial. Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences. 2017;22:98. doi:10.4103/jrms.JRMS_1_17.
A scientific review: the role of chromium in insulin resistance. Diabetes Educ. 2004;Suppl:2-14.
Hua Y, Clark S, Ren J, Sreejayan N. Molecular Mechanisms of Chromium in Alleviating Insulin Resistance. The Journal of Nutritional Biochemistry. 2012;23(4):313-319. doi:10.1016/j.jnutbio.2011.11.001.
- Juan A. Cooper, Bryan F. Anderson, Paul D. Buckley, Leonard F. Blackwell; Structure and biological activity of nitrogen and oxygen coordinated nicotinic acid complexes of chromium; Inorganica Chimica Acta; Volume 91, Issue 1, January 1984, Pages 1–9
K. L. Olin, D. M. Stearns, W. H. Armstrong, C. L. Keen; Comparative retention/absorption of 51chromium (51Cr) from 51Cr chloride, 51Cr nicotinate and 51Cr picolinate in a rat model; Trace Elements and Electrolytes; 1994; 182-186;
Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis. 2013;3(2):93–102. doi:10.1016/S2222-1808(13)60052-3
- Cefalu, W. T., & Hu, F. B. (2004). Role of Chromium in Human Health and in Diabetes. Diabetes Care, 27(11), 2741 LP – 2751. https://doi.org/10.2337/diacare.27.11.2741