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PYRETIC
PYRETIC
PYRETIC
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PYRETIC

$49.99
DESCRIPTION

What is Pyretic?

Pyretic is our take on the stimulant-free fat loss support formula that uses only natural ingredients to support fat burning, metabolism, and appetite suppression.*

By using this multi-factorial approach to weight loss, Pyretic stands apart from other thermogenic fat burning supplements on the market.*

The best part is, there are absolutely no stimulants whatsoever!*

Maximizing fat loss and achieving a ripped physique demands consistency and effort at the gym and in the kitchen. Pyretic is not a "quick fix" fat loss pill like other brands claim, but when combined with a proper nutrition plan and training program, it may enhance results.*

Pyretic Ingredients

Acetyl L-Carnitine (500mg)

Think of carnitine as the “little fat burning engine that could.” Carnitine is a naturally-occurring compound found in the mitochondria helps convert fat into useable energy. Supplementing with carnitine supports its function in the body, and may allow for more efficient fat burning.*

The problem is that regular L-Carnitine supplements aren’t particularly useful or effective in the average person -- it’s really only helpful to vegans and the elderly, people deficient in carnitine.*

However, Acetyl L-Carnitine (ALCAR) is extremely bioavailable, due to its ability to cross the blood-brain barrier (BBB) and exerts a number of remarkable benefits in the body.*[1]

Chief among these, ALCAR encourages the uptake of fatty acids into mitochondria, which encourages fat burning!*[2]

On top of that, ALCAR also exerts a number of cognitive benefits since it crosses the BBB. In particular, ALCAR may help lessen mental fatigue, improve mood, and support learning.*[3,4,5,6]  

  • Acetylated form of L-Carnitine that is bioavailable and crosses the blood-brain barrier*
  • Supports production of carnitine, a compound involved in fat burning*
  • May help reduce mental fatigue and increase mental energy*

Green Tea Extract (200mg)

Green Tea is considered one of the healthiest beverages on the planet. The leaves of green tea are rich in polyphenols, including catechins and flavonoids, which serve as antioxidants in the body, helping combat inflammation and oxidative stress.*
Primeval Labs has standardized the green tea extract in Pyretic for 50% EGCG, the most well-researched of all the tea polyphenols!*
Green Tea Extract, as well as EGCG in particular, have been shown in research trials to increase fat oxidation and energy expenditure both at rest and during exercise as well as enhance athletic performance!*[7,8,9]
Plus, green tea extract has also been documented to help decrease body fat and waist circumference, reduce caloric intake during meals, and limit the amounts of carbohydrates absorbed from a meal.*[10]

  • Rich in polyphenols and antioxidants which offer antioxidant protection from oxidative stress*
  • Support increase fat burning and energy expenditure*
  • Catechins in green tea have been shown to inhibit oxidation, vascular inflammation, atherogenesis, thereby supporting cardiovascular health*

Coleus Forskohlii 10% (125mg)

When it comes to stimulant-free fat burning ingredients Coleus Forskohlii (Forskolin) is as good as it gets! Forskolin assists weight loss by increasing cAMP (cyclic adenosine monophosphate) levels in the body.[11] cAMP is a derivative of ATP that serves as a chemical messenger involved in numerous biological processes.*
Activation of cAMP ignites lipolysis (the breakdown of fat stores in the body) while also inhibiting fat synthesis in the body.[12,13] In other words, forskolin may help liberate stored fatty acids to be oxidized for energy and limit fat synthesis.*

Additional research indicates that forskolin may reduce appetite and help preserve lean muscle mass while dieting.*

  • Studies have shown Forskolin stimulates an increase in the levels of cAMP, an important chemical messenger involved in metabolism*
  • Forskolin stimulates the release of stored fat from fat cells*
  • May promote fat loss while preserving muscle mass*

Cyanidin-3-Glucoside (125mg)

Chances are you’ve never come across Cyanidin-3-Glucoside in any other fat burner on the market, stimulant-based or not! But, Cyanidin-3-Glucoside, C3G, is one of the ingredients that make Pyretic truly exceptional!

C3G is a naturally-occurring anthocyanidin present in the dark-colored portions and skins of dark purple fruits, including blueberries and blackberries. C3G helps cultivate fatty acids to be used energy while at rest or during low-intensity exercise, thereby sparing your glycogen stores for more intense activities, such as sprinting.[16]

This potent compound also functions as a powerful alpha-amylase inhibitor.[17] In case you weren’t aware, alpha-amylase is one of the salivary enzymes found in the mouth helps digest starch.[18] What this means is that C3G basically acts as a carb blocker, preventing your body from fully processing some of the starches in the food you eat!

  • Naturally occurring antioxidant present in the skins of dark-colored fruits reported to counteract oxidative stress*
  • May enhance gene expression for fat oxidation*
  • Noted in research to inhibit alpha-amylase, an enzyme involved in carbohydrate digestion*
  • Animal studies indicate C3G has anti-obesity effects and may reduce the accumulation of fat in visceral adipose and liver tissues as well as plasma triglyceride levels*

Olea Europaea Leaf Extract 20% (100mg)

Olea Europaea, more commonly known as the“European Olive”, is a small species of the olive family littered throughout the Mediterranean region. Olive leaf extracts are another of the “proven commodities” when it comes to effective stim-free fat loss agents.*

Olive leaf extracts have been shown in research to help improve insulin sensitivity and defend against LDL (“bad”) cholesterol oxidation, primarily due to its high oleuropein content.[19] Furthermore, olive leaf extracts also have been noted to impact thyroid hormone production[20], supporting increased energy expenditure.*

  • Rich in antioxidants*
  • Supports thyroid function*
  • May promote insulin sensitivity*

Bacopa Monnieri (100mg)

When you’re dieting, calories are low, energy is low, and you’re most likely going to be cranky, hungry, and irritable. That’s where the stress-relieving qualities of Bacopa Monnieri come in!*

A staple of Ayurveda, Bacopa Monnieri is a versatile nootropic and adaptogenic herb frequently supplemented to reduce stress and improve cognition and focus.[21,22] By improving the body’s stress response, Bacopa may help alleviate stress or “brain fog” that can set in during periods of low-calorie intake.*
Bacopa monnieri also has been shown to positively impact the production of T4, an important thyroid hormone T4.*[23]

  • Ayurvedic herb noted for its ability to help reduce stress and improve memory and cognition*
  • Also noted in research to impact thyroid hormone production*

 

CAPROS® (100mg)

CAPROS® is an all natural, organic, non-GMO extract derived from the edible fruits of Phyllanthus Emblica, more commonly known as Amla. Numerous human research studies have shown that CAPROS supports heart health by improving endothelial function and cholesterol levels.[24]*

Other studies indicate that Amla fruit may also help regulate blood glucose levels[25]

When blood glucose is chronically high, insulin levels rise, hunger increases, and the body is more prone to start storing fat.*

  • Organic, non-GMO extract derived from Amla fruit*
  • Noted in human research to support cardiovascular health and endothelial function*
  • May help promote healthy blood sugar levels*

GS15-4™ (25mg)

Ginseng has been used for over 5000 years as an essential component of Traditional Chinese Medicine. The herb is most popularly supplemented for its adaptogenic qualities, where it helps the body deal with all sorts of emotional, psychological and physical stressors.*

The reason Ginseng is so powerful is due to the potent compounds contained in the plant known as ginsenosides. GS-14 is a trademarked extract of Panax ginseng (the one true ginseng on the market) that has been clinically proven to have superior absorption and bioavailability in the body.*

In addition to its energy and cognitive boosting benefits, ginseng also has been noted to offer anti-obesity effects via its actions on certain mechanisms which lead to decreased food intake, reduced blood glucose and lowered blood lipid levels.*[26,27,28]

  • Herb commonly used in traditional Chinese medicine to help reduce stress*
  • Rich in ginsenosides*
  • May help reduce food intake and blood sugar levels*

Chromium Picolinate (200mcg)

Chromium is a well-known mineral that’s involved in a number of highly critical functions in the body, including the production of cholesterol.*

Additionally, chromium is also required for the proper functioning of insulin. Without adequate chromium, insulin metabolism may be impaired, thereby affecting the uptake and utilization of glucose, amino acids, and fats.
Chromium has been noted in some research to help maintain steady blood sugar levels.[29,30], Stable blood sugars may help limit energy highs and lows that can occur as well as reduce spikes in hunger levels.*

  • Trace mineral involved in numerous physiological processes, including insulin metabolism*
  • Research notes that individuals with Type 2 diabetes have lower chromium levels than individuals without the disease*
  • May improve insulin sensitivity and glucose metabolism* 

Suggested Use

Consume 3 capsules in the morning and 3 capsules in the evening for a total of 6 capsules daily.

Disclaimer:

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease

References

 

  1. Vermeulen RC, Scholte HR; Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Psychosom Med. (2004)
  2. Sachan DS, Hongu N; Increases in VO2max and metabolic markers of fat oxidation by caffeine, carnitine, and choline supplementation in rats . J Nutr Biochem. (2000)
  3. Parnetti L, et al; Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type . Eur J Clin Pharmacol. (1992)
  4. Soczynska JK, et al; Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders . Expert Opin Investig Drugs. (2008)
  5. Ando S, et al; Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats . J Neurosci Res. (2001)
  6. Sano M, et al; Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer’s disease . Arch Neurol. (1992)
  7. Boschmann M, Thielecke F. The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study. J Am Coll Nutr. 2007;26(4):389S-395S.
  8. Auvichayapat P, Prapochanung M, Tunkamnerdthai O, et al. Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial. Physiol Behav. 2008;93(3):486-491. doi:http://dx.doi.org/10.1016/j.physbeh.2007.10.009.
  9. Hodgson AB, Randell RK, Jeukendrup AE. The Effect of Green Tea Extract on Fat Oxidation at Rest and during Exercise: Evidence of Efficacy and Proposed Mechanisms. Advances in Nutrition. 2013;4(2):129-140. doi:10.3945/an.112.003269.
  10. Lochocka K, Bajerska J, Glapa A, et al. Green tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover study. Scientific Reports. 2015;5:12015. doi:10.1038/srep12015.
  11. Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res 1981;7:201-24.
  12. Allen DO, Ahmed B, et al. Relationships between cyclic AMP levels and lipolysis in fat cells after isoproterenol and forskolin. J Pharmacol Exp Ther. 1986;238:659-64.
  13. Henderson S, Magu B, Rasmussen C, et al. Effects of Coleus Forskohlii Supplementation on Body Composition and Hematological Profiles in Mildly Overweight Women. Journal of the International Society of Sports Nutrition. 2005;2(2):54-62. doi:10.1186/1550-2783-2-2-54.
  14. Godard, M. P., Johnson, B. A. and Richmond, S. R. (2005), Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men. Obesity Research, 13: 1335–1343. doi:10.1038/oby.2005.162
  15. Godard, M. P., Johnson, B. A. and Richmond, S. R. (2005), Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men. Obesity Research, 13: 1335–1343. doi:10.1038/oby.2005.162
  16. Tsuda T, et al. Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem Biophys Res Commun. (2004)
  17. Homoki JR, Nemes A, Fazekas E, et al. Anthocyanin composition, antioxidant efficiency, and alpha-amylase inhibitor activity of different Hungarian sour cherry varieties (Prunus cerasus L.). Food Chem. 2016;194:222-229. doi:10.1016/j.foodchem.2015.07.130.
  18. Sales PM, Souza PM, Simeoni LA, Silveira D. alpha-Amylase inhibitors: a review of raw material and isolated compounds from plant source. J Pharm Pharm Sci. 2012;15(1):141-183.
  19. De Bock M, Derraik JGB, Brennan CM, et al. Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial. Nerurkar PV, ed. PLoS ONE. 2013;8(3):e57622. doi:10.1371/journal.pone.0057622.
  20. Al-Qarawi AA, Al-Damegh MA, ElMougy SA Effect of freeze dried extract of Olea europaea on the pituitary-thyroid axis in rats. Phytother Res. (2002)
  21. Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, & Nathan PJ. (2001). The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology. 156(4), 481-4.
  22. Rai D, Bhatia G, Palit G, Pal R, Singh S, & Singh HK. (2003). Adaptogenic effect of Bacopa monniera (Brahmi). Pharmacology, Biochemistry, and Behavior. 75(4), 823-30.
  23. Kar A, Panda S, & Bharti S. (2002). Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. Journal of Ethnopharmacology. 81(2), 281-5.
  24. Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2013;6:275-284. doi:10.2147/DMSO.S46341.
  25. Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-616. doi:10.3109/09637486.2011.560565.
  26. Lin N, Cai D-L, Jin D, Chen Y, Shi J-J. Ginseng panaxoside Rb1 reduces body weight in diet-induced obese mice. Cell Biochem Biophys. 2014;68(1):189-194.
  27. Attele AS, et al; Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component . Diabetes. (2002)
  28. Reay JL, Kennedy DO, Scholey AB; Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol. (2005)
  29. Paiva AN, Lima JG de, Medeiros ACQ de, et al. Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. J Trace Elem Med Biol. 2015;32:66-72.
  30. Roginski EE, Mertz W; Effects of Chromium (III) Supplementation on Glucose and Amino Acid Metabolism in Rats Fed a Low Protein Diet . J Nutr. ()
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