You’ve just completed one of the most aggressive and successful pro hormone cycles you’ve ever run, and now it’s coming to an end. You know it’s necessary to run some form of post cycle therapy (PCT), but can’t decide what is needed or how much or even when to take it.
Primeval Labs has addressed every single one of your PCT needs in Sanctuary. No need to purchase multiple products to form a “stack”, no more guessing games, no more worrying.
Sanctuary makes proper PCT simple, effective, and affordable. It restores proper hormonal homeostasis, enhances libido, strength, and natural testosterone production all in one simple daily serving. Your mood will be greater, your recovery will be faster, and your most vital organs will be protected.
Simply put, Sanctuary is the most comprehensive, complete PCT product ever released. Period!
Problems with other PCT Supplements
They use proprietary blends
They don’t include efficacious doses
Formulas aren’t based on clinically backed ingredients
Doesn’t provide comprehensive coverage and protection
Why Choose Sanctuary?
The answer is rather simple -- Sanctuary is your one-stop shop for comprehensive and effective post cycle therapy. There’s no need to source multiple products to address all of your needs coming off an aggressive pro hormone cycle. Everything you need is right here is one complete formula.
Sanctuary uses on the most effective, clinically proven ingredients in their research-backed doses to offer the protection and support you need, when you need it most. Sanctuary ensures that you keep whatever gains you made from your cycle for the long term while at the same time protecting your most vital of internal organs.
Benefits of Sanctuary
Liver & Organ Support
Enhances natural Testosterone Production
Supports Sexual Performance
Enhances Lean Mass
Prevents Fat Gain
Improves overall mood and well-being
Increases strength and overall athletic performance
The list of benefits goes on and on when choosing a comprehensive Post Cycle Therapy supplement, now let’s see just how each of the ingredients in Sanctuary contributes to the long list of benefits!
Bulbine Natelensis (750mg) : Bulbine natalensis is a South African herb with a long history of use as both an aphrodisiac and natural testosterone booster. Research notes that Bulbine Natalensis elevates testicular and serum testosterone levels, Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and even testicle size![1,2] Furthermore, supplementing with Bulbine Natalensis has been shown to effectively reduce estrogen levels in the body -- a major concern when coming off cycle! But that’s not quite the end of Bulbine’s benefits. It also enhances sexual performance too! Specifically, Bulbine enhances mount frequency, ejaculation frequency and latency, as well as intromission frequency. Quite simply, coming off cycle can stunt sex drive and performance, and Bulbine is precisely what you need to get back on your game.
Tribulus (750mg): An ingredient commonly seen in many natural testosterone boosters, Tribulus Terrestris is an Ayurdeic herb renowned for its ability to significantly enhance male virility and vitality. Also known as Devil’s Weed,Tribulus is able to significantly enhance male libido and performance due to its high saponin content.[5,6,7] Newer research has documented that the potent herb actually increases Testosterone (+12%), IGF-1 (+20%), maintains lean body mass, AND reduces body fat by an average of 2kg (7%) and maintained lean mass! What’s really impressive is that those trials were conducted using middle-aged men (ages 45-60), who certainly have experienced declining testosterone levels over the years. These results bode well for those coming off cycle who would experience a similar dip in Testosterone production!
Atractylodes Macrocephala (500mg): Atractylodes macrocephala is a Chinese medicinal herb extensively used to treat a variety of digestive diseases in China and many other countries across Asia. Modern research indicates extracts of the herb are beneficial for stimulating mitochondrial function and energy metabolism in muscle as well as combatting assorted forms of cancer cells.[9,10] Most to the point of its inclusion in Sanctuary, Atractylodes is rife with a number of potent bioactive compounds known as atractylenolides. In vitro studies on atractylenolide note an exceptionally strong ability to inhibit aromatase, with atractylenolide 1 possession a 94.5% inhibition ratio. This ingredient is one of the primary features that separates Sanctuary from virtually every other PCT supplement on the market!
Magnesium (450mg): An essential mineral, magnesium is required for a wide range of biological processes including blood sugar regulation, energy production, muscle function, protein synthesis, and DNA construction, just to name a few.[12,13,14] Although magnesium is one of the most abundant minerals in the body, it’s also one of the most common nutrient deficiencies in adults -- especially athletes! This spells trouble for men in particular, as chronically deficient levels of magnesium have been shown to negatively impact testosterone production in the body. To combat this common deficiency, Sanctuary includes 450mg of Magnesium Aspartate -- one of the most bioavailable forms of magnesium around!
Mucuna Pruriens (300mg): Also known as Velvet Bean, Mucuna Pruriens is a medicinal plant renowned for its high concentrations of L-Dopa, the precursor to the neurotransmitter dopamine. Sanctuary uses an extract standardized for 99% L-Dopa, the highest quality extract around! Why is this good? L-Dopa easily crosses the blood-brain barrier (BBB), where it can work its magic on hormones, especially prolactin. Clinical trials have shown that L-Dopa significantly inhibits prolactin release from the anterior pituitary, which means you’ll avoid any of the nasty side effects attributed to high prolactin levels (such as liver or kidney disease!) by supplementing with L-Dopa. As a precursor to dopamine, L-Dopa can significantly increase dopamine levels, which has the twofold effect of inhibiting prolactin and elevating mood! In addition to its vital role in prolactin control, L-Dopa also enhances libido and some other research has shown it successfully boosts testosterone and luteinizing hormone (LH), while also lowering cortisol levels.[18,19] This sets the stage for an optimal hormonal environment in favor of muscle-building, overall well-being, and your sex life!
Maca Root (250mg): Alternatively referred to as Peruvian Ginseng, Maca is an adaptogen and a member of the cruciferous family of vegetables (i.e. broccoli, cauliflower, etc.). It has a long history of use as both a medicine and as an all natural way to boost vitality and fertility. As it turns out, those ancient Peruvian tribes were onto something with Maca. Several clinical trials have shown that not only does it improve libido, but also fertility and sexual desire.[20,21] There’s quite a bit more to this super vegetable though. Maca is already useful for improving endurance, learning and memory. Add to this the fact that some animal studies show it successfully decreases prostate size, and its inclusion in Sanctuary is a no-brainer!
DIM (200mg): Short for Diindolylmethane, DIM is the main bioactive constituent of indole-3-carbinol (I3C) -- a powerful compound found in all sorts of cruciferous vegetables. Research into DIM and I3C show it's incredibly powerful at combating assorted forms of cancer cells but more the the point of its inclusion in Sanctuary, DIM is also an effective estrogen blocker and aromatase inhibitor. DIM exerts its effects in a few different ways, but the takeaway is that they ALL result in decreased estrogen levels. Specifically, DIM stimulates Phase I enzymes -- activating AhR which yields more “good estrogen” and less “bad estrogen” -- as well as increases 2-hydroxyestrone (a “good” estrogen).
N-Acetyl L-Cysteine (150mg): N-Acetyl L-Cysteine (NAC) is well known for its antioxidant and liver protecting abilities.[25,26,27] NAC is the primary substrate for glutathione, a non-essential amino acid that’s responsible for scavenging free radical from around the body. This essentially makes glutathione an incredibly powerful antioxidant.[28,29] If your body is deficient in NAC, it don’t have the required “building blocks” to synthesize glutathione, which can lead to an accumulation of reactive oxygen species (ROS) and oxidative stress. In case you weren’t aware oxidative stress is often a side effect of prohormone use! Supplementing with AC increases glutathione which effectively helps decrease ROS formation and supports optimal liver function.
5a-hydroxy-laxogenin (50mg) : More commonly known as purely Laxogenin, 5a-hydroxy-laxogenin is a steroidal sapogenin extracted from the plant Smilax Sieboldii, a relative of the vegetable asparagus. Sapogenins are a specific form of plant steroid termed brassinosteroids present in the pollen, leaves, and seeds of numerous plants. Research has shown that laxogenin effectively stimulates muscle protein synthesis and aids cortisol regulation. Moreover, laxogenin enhances strength, performance, and recovery -- all factors that can decrease when coming off cycle. Suffice it to say, this is one plant that’s bringing some serious power!
Zinc (30mg): The relationship between Zinc, testosterone, and sexual health has been clearly identified by research on numerous occasions. Not only that, but this essential mineral also supports optimal immune system function and numerous enzymatic processes. Intensive training depletes mineral and vitamin stores rapidly, making high level athletes particularly susceptible to nutrient deficiencies, especially zinc. Deficiencies in zinc are associated with reduced testosterone production and low libido. Something no guy ever wants! To further drive home the point of just how crucial zinc is, having optimal zinc stores also improves IGF-1 release, a vital hormone for exercise recovery and growth. Case in point, if you want to train intensely, make gains, and keep up in the bedroom, you want adequate zinc!
BioPerine® (5mg): BioPerine® is the industry-leading patented black pepper extract included in Sanctuary to ensure every milligram of testosterone-boosting, estrogen-reducing, aromatase-inhibiting magic. BioPerine® is your “absorption insurance” that everything you put in your body is put to good use with maximum efficacy.
Vitamin D3 (1,000IU):
Vitamin D, also known as the “sunlight vitamin”, is an essential fat-soluble vitamin that the vast majority of the population is chronically low in, primarily due to too much time spent indoors and not enough time out in the sun.
Research shows that men deficient in Vitamin D are not only low in free testosterone, but also have higher estrogen levels. Additionally, those same men had higher body fat, less lean muscle mass, lower fertility, greater depression, and greater risk of cardiovascular disease than men with optimal Vitamin D levels.
Conversely, another trial took men with deficient Vitamin D levels and had them supplement with the vitamin and found they were able to increase testosterone levels by as much as 20 percent! Additionally, it’s also believed that Vitamin D helps inhibit aromatization, which would be another method to indirectly boost testosterone production.
Consume 1 serving (i.e. ALL 7 capsules) once per day. Do not use Sanctuary for longer than 8 weeks continuously. Take at least 8 weeks off between cycles.
The Difference is CLEAR
Sanctuary cuts no corners with its ingredients or dosing. Each ingredient is procured from the highest quality sources, so you know what’s on the label is in the tub. Your health isn’t worth gambling on a lesser quality product.
Sanctuary is your one stop shop for complete and effective post cycle therapy!
Yakubu MT, Afolayan A; Anabolic and androgenic activities of Bulbine natalensis stem in male Wistar rats . Pharm Biol. (2010) http://www.ncbi.nlm.nih.gov/pubmed/20645801
Yakubu MT, Afolayan AJ; Reproductive toxicologic evaluations of Bulbine natalensis Baker stem extract in albino rats . Theriogenology. (2009) http://www.ncbi.nlm.nih.gov/pubmed/19410284
Shindel AW, et al; Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo . J Sex Med. (2010) http://www.ncbi.nlm.nih.gov/pubmed/20141584
Yakubu, M. T. and Afolayan, A. J. (2009), Effect of aqueous extract of Bulbine natalensis (Baker) stem on the sexual behaviour of male rats. International Journal of Andrology, 32: 629–636. doi:10.1111/j.1365-2605.2008.00910.x. https://www.ncbi.nlm.nih.gov/pubmed/18710410
Singh S, Nair V, Gupta YK; Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats. J Pharmacol Pharmacother. (2012) http://www.ncbi.nlm.nih.gov/pubmed/22368416
Do J, et al; Effects and Mechanism of Action of a Tribulus terrestris Extract on Penile Erection . Korean J Urol. (2013) http://www.ncbi.nlm.nih.gov/pubmed/23526694
Wilk, Michal, et al; “Endocrine Responses to Physical Training and Tribulus Terrestris Supplementation in Middle-Age Men”; Central European Journal of Sport Sciences and Medicine; Vol. 13, No. 1, 2016: 65–71; http://psjd.icm.edu.pl/psjd/element/bwmeta1.element.psjd-649c060c-d07d-466b-85af-0357a4a5cd5e/c/CEJSSM_13_1-2016_06_Wilk_etAl.pdf
Song MY, Kang SY, Oh TW, Kumar RV, Jung HW, Park Y-K. The Roots of Atractylodes macrocephala Koidzumi Enhanced Glucose and Lipid Metabolism in C2C12 Myotubes via Mitochondrial Regulation. Evidence-based Complementary and Alternative Medicine : eCAM. 2015;2015:643654. doi:10.1155/2015/643654.
Zhou J, Qu F, Yu Y. Chemical and Ecological Evaluation of a Genuine Chinese Medicine: Atractylodes Macrocephala Koidz. African Journal of Traditional, Complementary, and Alternative Medicines. 2011;8(4):405-411.
Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala koidz. Molecules. 2011;16(4):3146-3151. doi:10.3390/molecules16043146.
Institute of Medicine (IOM). Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Washington, DC: National Academy Press, 1997.
Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:527-37.
Stephenson EW, Podolsky RJ; Regulation by magnesium of intracellular calcium movement in skinned muscle fibers . J Gen Physiol. (1977)
Marcello Maggio, Francesca De Vita, Fulvio Lauretani, et al., “The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men,” International Journal of Endocrinology, vol. 2014, Article ID 525249, 9 pages, 2014. doi:10.1155/2014/525249
Boden, G; “Influence of levodopa on serum levels of anterior pituitary hormones in man”; Neuroendocrinology. 1972;10(5):309-15; http://www.ncbi.nlm.nih.gov/pubmed/4350777
Müller, T; “Acute levodopa administration reduces cortisol release in patients with Parkinson’s disease”; J Neural Transm. 2007 Mar;114(3):347-50; http://www.ncbi.nlm.nih.gov/pubmed/16932991
Shukla, Kamla Kant et al.; “Mucuna pruriens improves male fertility by its action on the hypothalamus–pituitary–gonadal axis”; Fertility and Sterility, Volume 92, Issue 6, 1934-1940; http://www.fertstert.org/article/S0015-0282%2808%2903935-6/fulltext
Yamada T, et al. Effect of chronic L-dopa administration on serum luteinizing hormone levels in male rats . Toxicology. (1995)
Shin B-C, Lee MS, Yang EJ, Lim H-S, Ernst E. Maca (L. meyenii) for improving sexual function: a systematic review. BMC Complementary and Alternative Medicine. 2010;10:44. doi:10.1186/1472-6882-10-44.
Gonzales, G. F., Córdova, A., Vega, K., Chung, A., Villena, A., Góñez, C. and Castillo, S. (2002), Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia, 34: 367–372. doi:10.1046/j.1439-0272.2002.00519.x
Sanderson JT, Slobbe L, Lansbergen GW, Safe S, van den Berg M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2001;61(1):40-48.
Jellinck PH, Forkert PG, Riddick DS, Okey AB, Michnovicz JJ, Bradlow HL. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem Pharmacol. 1993;45(5):1129-1136.
Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. 2-hydroxyestrone: the “good” estrogen. J Endocrinol. 1996;150 Suppl:S259-65.
Ozaras R1, et al; N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat. World J Gastroenterol. (2003)
Caro AA1, et al; N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically . Alcohol Clin Exp Res. (2014)
Aydin S1, et al; N-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissue . Tohoku J Exp Med. (2002)
Winterbourn CC1, Metodiewa D; The reaction of superoxide with reduced glutathione . Arch Biochem Biophys. (1994)
Cardey B1, Foley S, Enescu M; Mechanism of thiol oxidation by the superoxide radical . J Phys Chem A. (2007)
Esposito D, Komarnytsky S, Shapses S, Raskin I. Anabolic effect of plant brassinosteroid. The FASEB Journal. 2011;25(10):3708-3719. doi:10.1096/fj.11-181271.
Kylie, M., et. al. (2006). The effect of exhaustion exercise on thyroid hormones and testosterone of elite athletes receiving oral zinc. Neuro Endocrinology Letters. 27(1-2): 247-252
Rocha ED de M, de Brito NJN, Dantas MMG, Silva A de A, Almeida M das G, Brandao-Neto J. Effect of Zinc Supplementation on GH, IGF1, IGFBP3, OCN, and ALP in Non-Zinc-Deficient Children. J Am Coll Nutr. 2015;34(4):290-299. doi:10.1080/07315724.2014.929511.
Lee DM, Tajar A, Pye SR, et al. Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol. 2012;166(1):77-85. doi:10.1530/EJE-11-0743.
Pilz S, Frisch S, Koertke H, et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res = Horm und Stoffwechselforsch = Horm Metab. 2011;43(3):223-225. doi:10.1055/s-0030-1269854.
Dahlquist DT, Dieter BP, Koehle MS. Plausible ergogenic effects of vitamin D on athletic performance and recovery. J Int Soc Sports Nutr. 2015;12(1):33. doi:10.1186/s12970-015-0093-8.
We recommend for this product to be taken by men only unless otherwise recommended by a doctor.