If you want to know how and why Dynamine is the next best pre workout stimulant, you want to read this article.
Not a year goes by that the sports nutrition industry isn’t inundated by a cavalcade of new ingredients, boasting to take human performance to heights unseen…and this year is no different.
Leading the charge of the best new ingredients of 2018 is a dynamic new pre workout stimulant / nootropic agent in Dynamine.
This close relative of caffeine and TeaCrine has been receiving high praise for its ability to enhance energy, focus, mood, and performance, and we’ve got all the information on this intriguing new compound below!
What is Dynamine?
The simplest way to explain what Dynamine is, would be to compare it to another compound known pretty well in the world of pre workouts and nootropics.
Essentially, Dynamine is a faster-acting, harder-hitting form of TeaCrine (theacrine).
Many of you that have tried some of the leading pre workouts of the past few years are well acquainted with TeaCrine, and know first-hand its incredibly long-lasting energy and focus.
But...the issue for many of us using TeaCrine in pre workouts is that we’re pretty much finished training by the time TeaCrine kicks in, due to the fact that it takes around 90-120 minutes to really “ramp up”, so to speak.
So, the developers of TeaCrine, Compound Solutions, set out to find a compound that delivered all of the same great effects as TeaCrine, but in a fraction of the time.
The result of their neverending research and development quest turned out to be a close relative of TeaCrine in Dynamine.
More on Dynamine
For the more science-oriented folks that are interested in the specifics of “what is Dynamine™”, this is the section for you. If you’re really just interested in what it does, the feel free to skip this portion, because it’s about to get deep in here….
Dynamine is actually the trademarked name for a compound called methylliberine.
Why call it Dynamine?
Well, for one thing, methylibering isn’t all that easy to say, and for a second thing, Dynamine sounds a hell of a lot cooler from a marketing standpoint. So, Compound Solutions settled on Dynamine, and the rest is history.
Dynamine (as well as TeaCrine) belong to a class of compounds known as methyluric acids (or methylurates), which are similar to methylxanthines (i.e. caffeine and theobromine), but slightly different in structure.
These structural differences, while they might look rather minor on paper translate to big changes in the manner in which they impact your brain and central nervous system.
The molecular formula for Dynamine™ is 2-methoxy-1,7,9 Tetramethyluric acid.
Compare that to the molecular formula for TeaCrine®’s (1,3,7,9 Tetramethyluric acid), and you biochemistry folks will note that the methyl group on the “3-position” of the TeaCrine molecule is “popped off” the ring and placed onto one of the oxygens (2-oxo) on the pyrimidine ring.
The result of this merry-go-round of molecules is a “methoxy” group, that increases lipid solubility. Additionally, this methyl movement also makes the new molecule less hydrophilic, which is awesome for the user because less hydrophilic compounds more readily cross the blood-brain barrier.
This newly created methoxy group may also be the reason Dynamine seems to hit harder and faster than TeaCrine, too.
Where Does Dynamine Come From?
Dynamine™ is derived from the same plant sources as all other purine alkaloids, including caffeine, theacrine, theobromine, theophylline, xanthine, and paraxanthine. The bountiful botanical that contains all of this CNS-boosting compounds is none other than Coffee robusta.
Now, many of you many think this is the same coffee as what you drink every morning, but it’s not. The bean from which you brew your morning joe is actually the fruit of the coffee arabica plant, not coffee robusta. While found in high amounts in robusta species, Dynamine (as well as TeaCrine) is not found as plentifully in the robusta species.
Dynamine™ can also be found naturally occurring in a few other botanical sources as well, including:
kucha (Camellia assamica var. Kucha)
Cupuaçu (pronounced. Koo-poo-ah-soo)
Note: While Dynamine can be found in some tea varieties, it is NOT present in Camellia sinensis (black or green tea).
Chances are most of you have never heard of Cupuaçu (Theobroma grandiflorum).
So, what is Cupuaçu?
It is a cacao-like tree native to the Amazon basin of Colombia, Peru, Brazil, and Bolivia. The fruit of Cupuaçu remembles cocoapods. These pods contain a white pulp, which is where they various alkaloids can be found.
How Does Dynamine Work?
Due to the novelty of Dynamine, there isn’t much to be found in terms of long-ranging clinical studies on the compound.[1,2,3] It’s brand new on the scene, and as such, the only way to really understand how and why Dynamine does what it does, is to go directly to the source...which is exactly what we did.
In speaking with the pioneers of Dynamine, Hector L. Lopez, M.D., CSCS, FAAPMR, FISSN, Tim Ziegenfuss, PhD, Shawn Wells, MPH, RD, and Compound SOlutions CEO Matt Titlow, we learned that methyluric acids [such as Dynamine (methyliberine) and TeaCrine® (theacrine)] are an exceptionally rare “breed” of compounds that are able to stimulate and activate the brain WITHOUT affecting heart rate, blood pressure, or vasoconstriction (pressor response).
In other words, Dynamine™ (as well as TeaCrine®) stimulates the central nervous system, without impacting your cardiovascular system.
So, unlike so many other stimulants that have you feel like your heart is about to burst out of your chest or have you struggling to catch your breath, Dynamine just ignites your mind with next to no impact on heart rate or blood pressure.
As an added bonus, this also means that Dynamine also exerts less of an impact on your adrenal glands than other stimulants, which helps reduce cortisol (stress) levels, too!
Dynamine Boosts Energy, Mood, and Focus
Due to the novelty of this compound, research is still ongoing to identify all of the mechanisms through which Dynamine impacts the central nervous system, but based on preliminary studies conducted by researchers, it appears that the pharmacodynamics of Dynamine™, relative to that of theacrine, is a bit different (most likely due to the structural variance between the two).
If you remember from above, we mentioned playing a game of “musical chairs with the methyl group”, the result of which allows Dynamine™ to more readily cross the blood-brain barrier (BBB), leading to a quicker onset of action (i.e. “harder hitting” and faster acting).
This also opens up the possibility that Dyamine may potentially stimulate dopamine receptors more powerfully than TeaCrine as well as cause greater downstream signaling of other neurotransmitters such as GABA, serotonin, or norepinephrine.
Compound Solutions has also postulated that it is antagonizes adenosine receptors in a manner similar to that of TeaCrine®. Thus giving it the energy and alertness boosting capabilities as that of caffeine.
Preliminary human studies on Dynamine have noted that the onset of action is substantially more dynamic (hence the name, Dynamine), with reports of test subjects noting enhanced energy, mood, and focus (EMF) about 10-15 minutes post ingestion with EMF peaking around the 45-60 minute mark.
Early studies have noted the enhanced energy, mood and focus (EMF) of Dynamine lasts around 2.5 to 3 hours and then begins to subside.
This makes Dynamine a significantly better option for inclusion in pre workouts, since it exerts its actions so quickly, as compared to TeaCrine, which can take up to two hours to really “get going”.
Anticipated Effects of Dynamine
So, what can you expect to feel when you take Dynamine?
Essentially, you’ll feel a “cognitive tickle” or “awakening” which is reminiscent of the “kick” you get from caffeine. But, the main difference between this heightened sense of mental energy and alertness from Dynamine as compared to caffeine is that it’s not actually placing a massive burden on your adrenal or cardiovascular system, in the manner in which caffeine does.
Remember, methylurates (i.e. methyluric acids) such as Dynamine act differently than methylxanthines (i.e. caffeine, theobromine, xanthine) due to the one oxygen group difference between the two. This results in the different impact on the cardiovascular system that we discussed in detail above.
Dynamine Doesn’t Affect Sleep
As an added bonus of the lack of cardiovascular and adrenal impact, Dynamine should not affect your ability to go to sleep at night, according to Compound Solutions. This is based on some findings from the preliminary human studies that gave subjects Dynamine late in the day and assessed their sleep quality using the PSQI (Pittsburgh Sleep Quality Index).
Due to this, this makes Dynamine a great ingredient to use anytime of day when you need to get hyped for a workout or late night study session, as it will awaken your cognitive abilities, yet when it’s time to go to bed, you can do so with ease.
How Much Dynamine?
Based on anecdotal feedback as well as the early research conducted by Compound Solutions, the “sweet spot” dose for Dynamine™ appears to be in the range of 100-200mg.
Additional research is ongoing to pin down a potential “ideal” dose, both in solo applications as well as in combination with other potent CNS-stimulating compounds, such as caffeine or TeaCrine.
Is Dynamine Safe?
Currently, Compound Solutions is conducting chromosomal aberration, genotoxicity studies, and mutagenicity studies to determine the long term safety of Dynamine, but based on early reports, as well as animal-based studies (LD50 and dose-range finding study), Dynamine appears to be safe.
Further testing is needed to provide a “no adverse effect level” and GRAS (generally recognized as safe) dose, as well as satisfy the criteria for “reasonable certainty of causing no harm under conditions of intended use.”
Currently, Compound Solutions has three human studies underway as well as a comprehensive toxicity rat study, which they hope to use the results from those studies to obtain a GRAS dose.
Is Dynamine Legal?
One of the best attributes about Dynamine, compared to other common pre workout stimulants, is that it is completely legal and naturally occurring. It’s not some franken-chemical concocted in a lab that will be outlawed in six months time.
Dynamine is found readily in Coffee robusta, a different species of the coffee plant than the kind you use for your morning brew, which is coffee arabica. And it’s also found in kucha, yerba mate, and cocoa.
All of these sources are provide proof that Dynamine is an all-natural constituent found in plants, unlike so many of the “designer” stims popping up in pre workouts these days.
What to Stack with Dynamine™
Caffeine + Dynamine™
Dynamine seems to exert the majority of its effects through antagonism of adenosine receptors and upregulation of dopamine. There’s no compound better for performing those two actions that caffeine.
As such, it makes perfect sense that stacking caffeine and Dynamine would make for the ultimate hard-hitting, fast-acting stack for increased energy, focus, and motivation.
The addition of caffeine may also enhance to bioavailability of Dynamine. The basis for this resides in a study which recently showed that when TeaCrine and caffeine were stacked, the bioavailability was significantly improved.
Due to the similarity of Dynamine and TeaCrine, it would stand to reason that the enhanced bioavailability would carry over this faster acting cousin of TeaCrine.
As far as dosing the two compounds together, we like to dose them:
Caffeine + TeaCrine® + Dynamine™
This stack is the perfect stack for energy that lasts all day long.
Caffeine and Dynamine provide the immediate spark you need to get your day off to a rocking start, and just as their effects are starting to wane, TeaCrine picks up to carry you on for an additional 3-4 hours.
The enhanced mental energy and focus make this stack ideal for those long days of work or study, when you’re grinding from dawn till dusk.
Caffeine + Choline + Dynamine
This stack is another personal favorite of our, especially for training and productivity.
The inclusion of choline upregulates production of acetylcholine, a neurotransmitter that affects memory, learning, cognition, mental processing, as well as muscle contractions.
During training, this means you may experience greater focus as well as a significantly stronger mind-muscle connection, enabling you to really “feel” each and every muscle fiber contracting.
Caffeine: 100-300mg (depending on preference)
Choline Bitartrate: 1-2g
What Supplements Use Dynamine?
If the prospect of this new super-stim has you chomping at the bit, eager with anticipation, you don’t need to look very far.
Primeval Labs has includes a massive 325mg dose of Dynamine 40% in every full serving of Mega Pre Black.
Mega Pre Black was formulated to be the consummate energy and performance pre workout that significantly boosts energy, with performance to match.
Dynamine -- The Best New Pre Workout Stimulant
Dynamine has erupted onto the pre workout scene and with it, a flurry of excitement and anticipation. It delivers everything that TeaCrine® was supposed to be, and a whole lot more.
Harder hitting, faster acting, and sure to help you push to new levels of athletic performance. It’s ideal for inclusion in pre workout supplements and that’s why we’ve included an industry-leading dose of 325mg in every serving of Mega Pre Black.
Clarke RJ, Macrae R. Coffee: Physiology. Springer Netherlands; 1988. https://books.google.com/books?id=oI6LtxfEKkwC.
Maier HG, Weidner M. Minor alkaloids in caffeine-containing beverages. Dtsch Leb. 2000;96(10):363-368. https://www.cabdirect.org/cabdirect/abstract/20003008257
Mazzafera P. Catabolism of caffeine in plants and microorganisms. Front Biosci. 2004;9:1348-1359. https://www.bioscience.org/2004/v9/af/1339/2.htm
He, H., Ma, D., Crone, L. B., Butawan, M., Meibohm, B., Bloomer, R. J., & Yates, C. R. (2017). Assessment of the Drug–Drug Interaction Potential Between Theacrine and Caffeine in Humans. Journal of Caffeine Research, 7(3), 95–102. https://doi.org/10.1089/jcr.2017.0006