Ape Sh*t Cutz
Ape Sh*t Cutz
$34.99
What is Ape Sh*t Cutz? Ape Sh*t Cutz is a thermogenic pre workout scientifically formulated to support increased athletic performance, endurance, and calorie burning. We’ve taken the best elements from our best-selling, high energy pre workout Ape Sh*t and added in prominent weight loss support agents to create the ultimate fat-burning pre workout supplement.* What’s the Difference Between Ape Sh*t & Ape Sh*t Cutz? The biggest difference between the original Ape Sh*t pre workout and Ape Sh*t Cutz is the swap of nitric oxide support ingredients for weight loss support agents. In lieu of L-Citrulline, Agmatine, and Taurine, we’ve included several compounds that help support fat metabolism and increased thermogenesis to help burn more calories during training.* Make no mistake though, Ape Sh*t Cutz still offers the same delicious flavor you’ve come to expect from all Primeval Labs supplements. In fact, we believe this may surpass the flavoring of the original Ape Sh*t!* Ape Sh*t Cutz Ingredients Beta Alanine Beta alanine is a prominent endurance support supplement known to support stamina and resistance to fatigue. It does so by increasing concentrations of a powerful intracellular buffer known as carnosine.*[1] With higher levels of carnosine, skeletal muscle is better able to buffer acidic (H+) ions that accumulate during repeated muscle contractions. This enables muscles to last longer before succumbing to fatigue, promoting greater stamina, strength, and endurance.*[2,3,4] Choline Bitartrate Choline is an essential nutrient that plays a key role in cognitive development, muscle movement, and the structure of cell membranes. It also serves as a building block for the “learning transmitter”, acetylcholine, which is well-known to impact focus, learning, memory, and the “mind-muscle connection.”* Supplementing with choline helps support acetylcholine production in the body promoting greater focus and a stronger mind-muscle connection during training.* Caffeine Caffeine is great for increasing mental energy, focus, and concentration. It’s also useful for supporting weight loss due to the facts that caffeine has been noted in various research trials[5,6,7,8] to help*: Enhance fatty acid oxidation* Increase lipolysis via cyclic AMP* Boost metabolic rate* Suppresse appetite This consummate pre workout stimulant also helps improve exercise performance by reducing perceived exertion, which may help athletes to train longer, banging out more reps and burning more calories.* Ape Sh*t Cutz utilizes natural caffeine from green tea to supply smooth, long-lasting energy without the jitters, edginess or crash.* Note: Each full serving (2 scoops) of Ape Sh*t Cutz supplies a total of 300mg caffeine from green tea. Garcinia Cambogia Garcinia cambogia is a small, sour-tasting, pumpkin-shaped fruit that is rich in hydroxycitric acid (HCA).* Research suggests that garcinia cambogia may help decrease oxidative stress, suppress appetite, and support weight loss efforts.*[18,19,20] Dandelion Extract Dandelion is a commonly used all-natural diuretic included to help shed unwanted water weight that tends to accumulate in the body. Research has shown that dandelion may increase urine output, as well as the frequency of urination, for up to 5 hours![9,10]*  Additional studies also suggest dandelion may enhance glucose uptake in skeletal muscle[11], promoting greater utilization and storage of carbohydrates.* Gamma-Butyrobetaine HCl (GBB) Gamma-butyrobetaine (GBB) acts as a carnitine precursor.* It is converted to carnitive via the enzyme Gamma-butyrobetaine dioxygenase (BBD).[12] Gamma-butyrobetaine dioxygenase is an oxidoreductase enzyme that mediates conversion of GBB to carnitine through the movement of electrons.[13]* Why is more carnitine beneficial? Carnitine is the molecule in the body that facilitates transportation of fatty acids into the mitochondria for beta-oxidation, a.k.a. “fat burning”. Greater carnitine availability allows for more fatty acids to be shuttled into the mitochondria to burn as fuel.* Be forewarned that GBB is known to have a prominent thermogenic effect in the body, so expect to feel the heat with Ape Sh*t Cutz!* Yohimbine Bark Extract Yohimbine is a bioactive compound found within the bark of the African tree, Pausinystalia johimbe. It has been noted to function as a powerful CNS stimulant that antagonizes alpha-2-adrenergic receptors in the body, which helps increase energy and focus while also supporting fat burning.*[14] Yohimbine has also been noted to help suppress appetite, helping individuals combat those notorious hunger pangs that arise during diets.*[15,16,17]  Disclaimer:  *These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease. References Baguet, A et al.; Journal of Applied Physiology; “Important role of muscle carnosine in rowing performance;” July 2010;” 2005 Roger C. Harris; et al.; “The effect of a supplement containing β-alanine on muscle carnosine synthesis, ventilatory threshold and exercise capacity in Korean cyclists, during 12 weeks combined endurance and weight training“ Hill, CA et al.; Amino Acids; “Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity ;” February 2007 Kendrick IP, et al. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. (2008) Hasselmo ME. The role of acetylcholine in learning and memory. Curr Opin Neurobiol. 2006;16(6):710–715. doi:10.1016/j.conb.2006.09.002 Institute of Medicine (US) Committee on Military Nutrition Research. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington (DC): National Academies Press (US); 2001. 2, Pharmacology of Caffeine. Available from: https://www.ncbi.nlm.nih.gov/books/NBK223808/ Schubert, M. M., Irwin, C., Seay, R. F., Clarke, H. E., Allegro, D., & Desbrow, B. (2017). Caffeine, coffee, and appetite control: a review. International Journal of Food Sciences and Nutrition, 1–12. https://doi.org/10.1080/09637486.2017.1320537 Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A., & Miller, D. S. (1989). Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. The American Journal of Clinical Nutrition, 49(1), 44–50. https://doi.org/10.1093/ajcn/49.1.44 Rácz-Kotilla E, Rácz G, Solomon A; The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals . Planta Med. (1974) Clare BA, Conroy RS, Spelman K. The Diuretic Effect in Human Subjects of an Extract of Taraxacum officinale Folium over a Single Day. Journal of Alternative and Complementary Medicine. 2009;15(8):929-934. doi:10.1089/acm.2008.0152. Higuchi N1, et al; Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease . Exp Ther Med. (2011) Strijbis K, Vaz F, Distel B; “Enzymology of the carnitine biosynthesis pathway”; IUBMB Life; 2010 May; 62(5):357-62;  Paul HS, Sekas G, Adibi SA (Feb 1992). “Carnitine biosynthesis in hepatic peroxisomes. Demonstration of gamma-butyrobetaine hydroxylase activity”. European Journal of Biochemistry / FEBS. 203 (3): 599–605. doi:10.1111/j.1432-1033.1992.tb16589.x. PMID 1735445 Murburg, M. M., Villacres, E. C., Ko, G. N., & Veith, R. C. (1991). Effects of yohimbine on human sympathetic nervous system function. The Journal of Clinical Endocrinology and Metabolism, 73(4), 861–865. https://doi.org/10.1210/jcem-73-4-861 Mizuki Y, et al; Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety . Prog Neuropsychopharmacol Biol Psychiatry. (1996) Galitzky J, et al; Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers . Eur J Clin Invest. (1988) Callahan MF, Beales M, Oltmans GA; Yohimbine and rauwolscine reduce food intake of genetically obese (obob) and lean mice . Pharmacol Biochem Behav. (1984) Onakpoya I, Hung SK, Perry R, Wider B, Ernst E. The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials. J Obes. 2011;2011:509038. doi:10.1155/2011/509038 Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem. 2002;238(1-2):89-103. doi:10.1023/a:1019911205672 Sripradha R, Sridhar MG, Maithilikarpagaselvi N. Antihyperlipidemic and antioxidant activities of the ethanolic extract of Garcinia cambogia on high fat diet-fed rats. J Complement Integr Med. 2016;13(1):9-16. doi:10.1515/jcim-2015-0020
APE SH*T
APE SH*T
$34.99
Everyone has had one of those days before. You know the kind we’re referring to….boss is on your case, cable repair guy stood you up, your brand new smartphone just fell in the toilet. Yeah, now you understand those days -- the really sh*tty ones that have you at wit’s end! These are the days when someone even looks at you cross, and you go Ape Sh*t! Going “Ape Sh*t”   Ape Sh*t (adj.) - To behave in an explosive manner; to act without regard, due to becoming enraged or extremely angry. It takes a certain confluence of events to drive someone absolutely ape sh*t. In the wrong setting, being in such an untamed fury can spell disaster, but in the right place (i.e. the gym), going ape shit can set the stand for record-shatter workouts, where it just rains PRs for the entire session. Wouldn’t it be great to have that same feeling day after day in the gym, without actually having a shitty day?!  Enter Ape Shi*t Pre Workout What is Ape Sh*t? Ape Sh*t is a high energy pre workout that supports increased energy, aggression, motivation and focus along with increased blood flow to boost performance and pumps.*  Ape Sh*t Ingredients L-Citrulline L-Citrulline is a premium nitric oxide support ingredient. It is an amino acid found prevalently in the flesh and rind of watermelon. Studies show it is superior to the old favorite NO-booster (L-Arginine) due to L-Citrulline’s higher bioavailability.[1]* With greater nitric oxide production, the stage is set for greater vasodilation, vascularity, and PUMPS!*There’s more to L-Citrulline than just vein-gorging pumps though, it’s also is known to support increased athletic performance.* Studies indicate that supplementing with L-Citrulline prior to training may enhance ATP production, boost endurance, and support lean body mass gains.*[2,3] Beta Alanine Tired of burning out mid set and leaving gains in the gym? Then, beta alanine might be just the thing your training needs.*When exercising, hydrogen (H+) ions accumulate in muscle tissue which drops the pH in muscles leading to an acidic environment. Once this occurs, that painful “burning” sensation hits like a Mack Truck, terminating the set.*Beta Alanine helps delay the onset of fatiuge and "beat back" the burn, by increasing carnosine concentrations in skeletal muscle.[4]* Higher levels of carnosine improve body’s buffering capacity to shuttle out those acidic ions, delaying that burning sensation, and increasing training capacity.*The end result is greater stamina, strength, and endurance.[5,6,7] Something any athlete, not just weightlifters, can benefit from!* Taurine When you’re going Ape Sh*t in the gym, you’re bringing everything you got, and that inevitably means you’re sweating your ass off! While that’s a strong indication you’re pushing the limits, it’s also a sign that you may be losing valuable electrolytes needed for hydration and muscle contraction!To support hydration and performance, Ape Sh*t contains TWO full grams of L-Taurine, a conditionally essential amino acid that functions as an osmolyte in the body.[8]* Taurine helps pull water into muscle cells, which improves hydration, cell volumization, muscle fullness, and endurance.*There’s more though! Taurine is also a highly underrated focus booster, as vast reserves of taurine are found in the brain, where it serves to enhance cognition and attention.[9]* Agmatine Sulfate (750mg) Agmatine is a multi-faceted nutrient that has a number of alluring properties.* Agmatine supports nitric oxide in two ways by stimulating eNOS and inhibiting arginase, the enzyme that degrades arginine (the amino acid responsible for N.O. production).[10] Limiting arginase activity supports greater Arginine levels, promoting greater nitric oxide production and longer-lasting muscle pumps!* Agmatine has also been noted to modulate pain receptors which may allow for longer training capacity.*  Choline Bitartrate Hitting the gym with unbridled aggression and rage is great if it’s focused on a singular goal. Without focus, that aggression just turns you into the typical bro jerk who’s screaming and dropping weights all over the ground -- and NO ONE likes that guy.* Choline is needed for the production of the learning transmitter acetylcholine, which promotes focus as well as the “mind-muscle connection”.[11]* Caffeine Caffeine is the consummate pre-workout stimulant.* It picks you up when you’re low on energy and helps motivate you to get the job done! For these exact reasons, Untamed Labs has included a synergistic trifecta of caffeine to provide both immediate and long-lasting energy.*Caffeine Anhydrous provides the jumpstart needed to get going in the gym, and the addition of Caffeine Citrate and Infinergy™ Dicaffeine Malate serve to further enhance energy levels, thereby helping Ape Sh*t hit harder and last longer.*The unique combination of caffeine variants is what sets Ape Sh*t from any other pre-workout on the market.* No crash, no headaches, no jitters -- just pure energy, focus, and motivation!* Yohimbine Bark Extract 8% Yohimbine is the active component of yohimbe extracted from Pausinystalia Yohimbe.*Yohimbine is an Alpha-2-Adrenergic receptor antagonist that works by increasing adrenaline and noradrenaline levels in the body, stimulating the “fight or flight” response, and thereby promoting alertness, energy, and motivation.[12] Yohimbine also supports fat burning by inhibiting a regulatory process in fat cells that stunts fat burning.* Toothed Clubmoss (Standardized to 1% Huperzine A) Huperzine supports increased acetylcholine levels by inhibiting acetylcholinesterase, the enzyme responsible for acetylcholine breakdown.*[13] Limiting acetylcholinesterase activity helps further enhance acetylcholine levels and prolongs its actions, promoting stronger focus and mind-muscle connection.*There’s more though! Huperzine  is also noted to possess neuroprotective qualities as it defends against glutamine (the neuron death molecule)[14], and supports the creation of new brain cells![15]* Suggested Use Consume 1-2 scoops with 8-10 oz of water 15-20 minutes prior to training to unleash your inner beast! Disclaimer: *These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.
EAA MAX ENERGY
EAA MAX ENERGY
$34.99
Primeval Labs rocked the amino acid supplement category when we released EAA Max. The product was downright delicious, but you wanted more! You wanted all the best aspects of EAA Max but with some extra energy to really get you going. Well, Primeval fans, your prayers have been answered as we’ve now created the ultimate amino energy supplement on the market in EAA Max Energy! Not only do you get a full 5g dose of 2:1:1 BCAAs along with a comprehensive spectrum of essential amino acids, you also get ample energy to crush a daunting workout or make it through another long afternoon at the office.* This is the answer to the common, over-priced energy drink that only provides caffeine with nothing else to offer.* EAA Max Energy provides all the energy you could want and it also supports muscle growth and recovery, giving you the best of both worlds in one affordable product.* When Can I Use EAA Max Energy? EAA Max Energy is perfect on training days as a pre workout or intra workout or on non-training days to support muscle growth and recovery. It can also be used as a replacement for your typical afternoon coffee or energy drink when you need a little “pick me up” to get through the day.* Mix a scoop into a half gallon water bottle, drink throughout the day, and kick those energy drinks and coffee cups to the curb.* Why Choose EAA Max Energy? Each serving of EAA Max Energy provides ALL of the essential amino acids required for muscle protein synthesis (including a full 5g of 2:1:1 BCAAs!) and a generous amount of caffeine to provide smooth, long-lasting energy that will have you on top of your game all day long.* Additionally, if you don’t consume a diverse diet, you may be missing out on some key EAAs needed for proper protein construction. EAA Max Energy may help “fill in the gaps” if diets missing one of those essential amino acids.* Not only does EAA Max Energy promote protein synthesis, it also supports increased energy production, muscle repair, and mitochondrial function.*[1] And, if you’re tired of chugging coffee, sickly sweet energy drinks, or underdosed BCAAs, EAA Max Energy may be just the thing you need!* EAA Max Energy Ingredients Stimulant Blend (286mg) There’s no other way to kick off EAA Max Energy’s ingredients than with the energy component of the product. Primeval Labs has crafted a powerful energy-boosting blend utilizing a trifecta of caffeine in the form of Infinergy Dicaffeine Malate, Caffeine Anhydrous, and Caffeine Citrate.*This scientifically-formulated blend of caffeine provides both immediate and sustained energy. There’s no jitters, anxiety, or crash here, only smooth, long-lasting energy.* Branch Chain Amino Acids L-Leucine Leucine is the “king” of all amino acids. It’s the most heavily researched BCAA and the one to which the vast majority of BCAA supplementation benefits are attributed. Leucine is the primary activator of mechanistic target of rapamycin (mTOR) pathway.*[2]Activating mTOR stimulates muscle protein synthesis and also enhances cellular growth, multiplication, metabolism, and survival.[3] On top of that, leucine is also essential for staving off catabolism (i.e. muscle protein breakdown), which ensures the gains you make are kept for good!* Stimulates mTOR -- the pathway that drives muscle protein synthesis* helps combat muscle breakdown* L-Isoleucine Typically thought of as Leucine’s weaker, younger brother, Isoleucine is also a stimulator of muscle protein synthesis, but not nearly as potent as Leucine is. However, one area that Isoleucine does shine is its ability to enhance the uptake of glucose by skeletal muscle as well as utilization of glucose during intense exercise.[4] In other words, Isoleucine improves the body's ability to store and use glucose while training allowing for more productive workouts and better gains!* stimulates muscle protein synthesis* Aids glucose uptake and utilization by skeletal muscle* L-Valine The third and final BCAA is Valine. It’s also the least individually researched of the three BCAAs.*Valine is vital for glycogen synthesis in muscle tissue as well as energy conversion[4] and forms the crucial third component of the branched-chain amino acid family.* Promotes glycogen resynthesis* Essential Amino Acids L-Lysine HCl (300mg) L-Lysine plays a number of important roles in regards to muscle building and athletic performance. It’s required for the production of carnitine - a substance that helps the body use fat for energy, and necessary for the creation of skin, cartilage, collagen, and tendons.* Furthermore, Lysine is also necessary for building proteins, enhancing calcium absorption, and accelerating recovery from injuries.*[5] Involved in carnitine production* Supports the body's use of fat for energy* Aids calcium absorption* L-Threonine (225mg) The very last amino acid discovered was Threonine.[6] It’s categorized as an alpha amino acid required for glycine and serine production, both of which are essential for fueling muscle protein synthesis. Threonine also works with aspartic acid and methionine (also found in EAA Max Energy) to support lipotropic function (fat digestion) in the liver.* Needed for the production of glycine and serine* Involved in fat digestion* L-Phenylalanine (200mg) Phenylalanine is a true rarity among amino acids, as it is one of the few compounds around that can cross the blood-brain barrier (BBB). This makes phenylalanine a critical component of healthy Central Nervous System function.[6] L-Tryptophan (50mg) L-tryptophan is the precursor to serotonin in the body, which means aside from it is essential for protein synthesis, it’s also essential for optimal serotonin production -- an important neurotransmitter for mood, behavior, and cognition.[*7] However, Tryptophan is the least abundant EAA in the body.[8] Deficiencies in this essential amino acids may lead to poor mood as well as reduced protein synthesis!* Several forms of Tryptophan can be found in amino acid supplements (DL-Tryptophan for example), but only the “L-” form is able to cross the blood-brain barrier and effectively be used for protein synthesis. Here is yet another example of Primeval Labs bringing only the best to its products!* Required for serotonin production* Due to its role in serotonin production, trytophan may support a healthy mood and better cognition* L-Histidine Histidine is vital to optimal cognitive function as well as wakefulness. It’s also a precursor to histamine.[9] In case you weren’t aware, histidine is required for the development and maintenance of the myelin sheaths that envelop nerve cells. Myelin sheaths also enhance signal transmission from the brain to all the other parts of the body.* This EAA is also essential for carnosine production, which is formed when beta alanine binds to histidine in muscle tissue.[10] Carnosine is an intracellular buffer that helps combat premature fatigue by removing H+ ions in the muscle.* Precursor to histamine* Supports neurotransmission via its involvement in maintenance of myelin sheath* Works with beta alanine to form carnosine* L-Methionine The final essential amino acid in EAA Max Energy is Methionine. Among the various roles Methionine plays in the body, is that of a precursor to L-Cysteine, an incredibly powerful antioxidant that combats oxidative stress induced by strenuous exercise.[11] L-Cysteine prevents free radical from accumulating in the body, and preventing inflammation -- ensuring health and wellness.* On top of that, Methionine is also a valuable lipotropic compound, which means it aids the liver in digesting fats.* Supports production of Cysteine* Aids fat metabolism* Muscle Energy & Nutrient Delivery Cluster Dextrin®(2,000mg) Cluster Dextrin® is the patented form of Highly Branched Cyclic Dextrin (HBCD), an fast-digesting carbohydrate source ideal for training. Cluster Dextrin’s unique structure gives it a high molecular weight and low osmolality, which means it is rapidly digested, but comes without the GI upset of other quick digesting carb sources.* Cluster Dextrin® is rapidly transported to skeletal muscles to provide energy and support amino acid delivery. The end result is better nutrient uptake for better muscle growth, repair, and recovery.* low-glycemic, fast-digesting carbohydrate* Supports athletic performance* Aids glycogen replenishment* D-Ribose (500mg) Ribose is a sugar produced from the breakdown of glucose in the body that combines with Adenine to form adenosine triphosphate (ATP), the main energy “currency” of the cell. D-Ribose is a supplemental form of Ribose used by athletes in improve athletic performance.* As you’re aware, during exercise, ATP stores become depleted, which negatively impacts performance. Supplementing with D-ribose has been shown to enhance ATP regeneration, supporting quicker inter-set recovery and increased training capacity.*[12,13] Exogenous form of ribose that supports athletic performance* Shown in research to aid ATP regeneration* May support faster intra-set recovery* Suggested Use Mix one scoop of EAA Max in 10-12oz of cold water and consume during exercise on training days. On non-training days, EAA Max Energy can be consumed throughout the day to support recovery and muscle building.* Disclaimer: *These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.
PyreticX  - Primeval Labs
PyreticX
$29.99
Pyretic X is a well-rounded thermogenic weight loss supplement formulated to help support increased thermogenesis, greater energy expenditure, and reduced body fat.* When combined with a reduced-calorie diet and exercise program, the ingredients in Pyretic X may help support dietary compliance and calorie burning, thereby promoting more efficient weight loss and better performance in the gym.* Pyretic X Ingredients Olive Leaf Extract (20% Oleuropein) Olive leaf extract is rich in numerous bioactive compounds, the most well-known of which is oleuropein.* Oleuropein is a versatile compound that has been noted in scientific research to possess a wide range of activities, including*:[1] Antioxidant Anti-inflammatory Anti-atherogenic Antimicrobial activity Antiviral activity Hypolipidemic hypoglycemic effect Oleuropein also stimulates BAT (brown adipose tissue), inhibits PPAR-γ receptor, and suppresses the proliferation of adipocytes (fat cells).*[2]  Oleuropein also enhances thermogenesis by increasing uncoupling protein-1 (UCP1).*[3] Additional research indicates that olive leaf extract supplementation may support better insulin sensitivity and help limit oxidation of LDL (“bad”) cholesterol.*[4] Animal studies also indicate that olive leaf extract supports thyroid function.*[5]  As you’re probably aware, the thyroid gland is critical to proper functioning of the metabolism.* Green Coffee Extract Green coffee beans are raw, unroasted coffee beans. They are rich in many pharmacologically active compounds, including chlorogenic acid.* Human studies note an inverse association between coffee intake and weight gain.[6]* Green coffee extract may help reduce body weight and fat mass, possibly due to reducing the amount of carbohydrate taken up by the intestines following a meal.* Researchers have theorized that green coffee extract may modify hormone secretion and glucose tolerance in humans.[7]* Green coffee extract’s primary bioactive, chlorogenic acid, appears to increase nitric oxide availability and possess antihypertensive effects.[8]*  Research also indicates chlorogenic acid reduces the hyperglycemic peak associated with carbohydrate ingestion.[9] This lowers insulin activity and may help reduce fat accumulation.* Natural Caffeine Caffeine is the well-known central nervous system (CNS) stimulant widely available in foods common to the diet, including coffee, tea, and dark chocolate.* Caffeine is best known for its ability to increase feelings of mental energy, due to its antagonism of adenosine receptors in the brain.* Regarding weight loss support, caffeine has been shown to help to boost metabolism, increase calorie burning, and enhance lipolysis (the “liberating” of stored fatty acids).[10,11]* Caffeine further supports weight loss by acting as a mild appetite suppressant, which may help reduce calorie intake at meal time.* Dieting on low calories is also known to lead to feelings of sluggish, lethargy, and a general lack of motivation to train hard.* Caffeine can help increase energy and motivation due to its ability to stimulate dopamine (“the mood and motivation” molecule) release in the brain, which increases mood, motivation and focus.[12]* Interestingly, dopamine also increases thermogenesis in brown adipose tissue, further increasing calorie burning.[13]* Theobromine Theobromine is a chemical cousin of caffeine and the principal alkaloid in Theobroma cacao (the cacao bean).[14] It’s also found in varying quantities in coffee and dark chocolate.* Theobromine is traditionally used as a bronchodilator and as a vasodilator as well as a diuretic.*[14,15] Research in animals shows that supplementation with a theobromine-rich cocoa powder encourages significant weight loss.[16]* Anecdotally, theobromine supplies a smoother, subtler, longer-lasting energy that complements the fast-acting energy of caffeine. It’s thought that combining the two may help limit the unwanted energy crash that accompanies high doses of caffeine.* This may be due, in part, to theobromine having a longer half-life than caffeine.[17]* Caffeine Anhydrous Pyretic X contains an additional 100mg of fast-acting caffeine anhydrous to further increase feelings of enhanced mental and physical energy to complement the smooth energy of Natural caffeine.* In total, Pyretic X contains 253mg of caffeine per full serving (2 capsules). Yohimbe Bark (8% Yohimbine) Yohimbine (pausinystalia johimbe) is a plant native to western and central Africa.* Extracts from yohimbe have long been used in traditional medicine as an aphrodisiac.* The primary active constituent in yohibe, yohimbine, is a prominent weight loss supplement due to its ability to antagonize (“block”) alpha-adrenergic receptors, thereby supporting fat burning.*[24] “Stubborn” fat areas have higher concentrations of alpha receptors and blocking them encourages increased fat-burning in those areas as greater amounts of fat-burning catecholamines (noradrenaline and adrenaline) can then bind to the beta receptors on fat cells.*  Yohimbine has also been explored as a potential ergogenic and body recomposition aid.[25]* Paradoxine® Paradoxine is a research-backed, patented extract of Grains of Paradise (Aframomum Melegueta) standardized to 12.5% 6-paradol.* 6-paradol is an aromatic ketone that is the major bioactive constituent of Grains of Paradise.* Research indicates that supplementation with Grains of Paradise extract may stimulate thermogenesis, increase energy expenditure, and decrease body fat.[18,19,20]* Cayenne Pepper Cayenne pepper contains the fiery alkaloid capsaicin which has been noted to possess some very enticing weight loss benefits.* Capsaicin has been noted in research to help reduce appetite and increase satiety by increasing glucagon-like peptide 1 (GLP-1) and decreasing ghrelin (the hunger hormone).[21]* Additional studies indicate that capsaicin can stimulate brown fat thermogenesis, which supports greater energy expenditure and calorie burning.[22]* Capsaicin may also help reduce appetite and calorie intake, due to its binding and activation of transient receptor potential vanilloid-1 (TRPV1) in the mouth, stomach and small intestine.[23]*  Activation of TRPV1 receptor stimulates the release of noradrenaline and dopamine, which have been noted to enhance weight loss and exercise performance.* SUGGESTED USE: Consume 2 capsules daily. To assess tolerance, it is suggested to begin with one capsule per day. Never exceed 4 capsules in any single 24-hour period. Disclaimer: *These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease. References Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm. 2010;78(2):133-54. Svobodova M, Andreadou I, Skaltsounis AL, Kopecky J, Flachs P. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014;9(1):376. doi:10.1007/s12263-013-0376-0 Oi-Kano Y, Kawada T, Watanabe T, et al. Oleuropein, a phenolic compound in extra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. J Nutr Sci Vitaminol (Tokyo). 2008;54(5):363-370. doi:10.3177/jnsv.54.363 De Bock M, Derraik JGB, Brennan CM, et al. Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial. Nerurkar PV, ed. PLoS ONE. 2013;8(3):e57622. doi:10.1371/journal.pone.0057622. Al-Qarawi AA, Al-Damegh MA, ElMougy SA Effect of freeze dried extract of Olea europaea on the pituitary-thyroid axis in rats. Phytother Res. (2002) Lopez-Garcia E, Van Dam RM, Rajpathak S, Willett WC, Manson JE, Hu FB. Changes in caffeine intake and long-term weight change in men and women. American Journal of Clinical Nutrition. 2006;83(3):674–680. Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. American Journal of Clinical Nutrition. 2003;78(4):728–733 Wong RH, Garg ML, Wood LG, Howe PR. Antihypertensive potential of combined extracts of olive leaf, green coffee bean and beetroot: a randomized, double-blind, placebo-controlled crossover trial. 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