Ape Sh*t Cutz
Ape Sh*t Cutz
$34.99
What is Ape Sh*t Cutz? Ape Sh*t Cutz is a thermogenic pre workout scientifically formulated to support increased athletic performance, endurance, and calorie burning. We’ve taken the best elements from our best-selling, high energy pre workout Ape Sh*t and added in prominent weight loss support agents to create the ultimate fat-burning pre workout supplement.* What’s the Difference Between Ape Sh*t & Ape Sh*t Cutz? The biggest difference between the original Ape Sh*t pre workout and Ape Sh*t Cutz is the swap of nitric oxide support ingredients for weight loss support agents. In lieu of L-Citrulline, Agmatine, and Taurine, we’ve included several compounds that help support fat metabolism and increased thermogenesis to help burn more calories during training.* Make no mistake though, Ape Sh*t Cutz still offers the same delicious flavor you’ve come to expect from all Primeval Labs supplements. In fact, we believe this may surpass the flavoring of the original Ape Sh*t!* Ape Sh*t Cutz Ingredients Beta Alanine Beta alanine is a prominent endurance support supplement known to support stamina and resistance to fatigue. It does so by increasing concentrations of a powerful intracellular buffer known as carnosine.*[1] With higher levels of carnosine, skeletal muscle is better able to buffer acidic (H+) ions that accumulate during repeated muscle contractions. This enables muscles to last longer before succumbing to fatigue, promoting greater stamina, strength, and endurance.*[2,3,4] Choline Bitartrate Choline is an essential nutrient that plays a key role in cognitive development, muscle movement, and the structure of cell membranes. It also serves as a building block for the “learning transmitter”, acetylcholine, which is well-known to impact focus, learning, memory, and the “mind-muscle connection.”* Supplementing with choline helps support acetylcholine production in the body promoting greater focus and a stronger mind-muscle connection during training.* Caffeine Caffeine is great for increasing mental energy, focus, and concentration. It’s also useful for supporting weight loss due to the facts that caffeine has been noted in various research trials[5,6,7,8] to help*: Enhance fatty acid oxidation* Increase lipolysis via cyclic AMP* Boost metabolic rate* Suppresse appetite This consummate pre workout stimulant also helps improve exercise performance by reducing perceived exertion, which may help athletes to train longer, banging out more reps and burning more calories.* Ape Sh*t Cutz utilizes natural caffeine from green tea to supply smooth, long-lasting energy without the jitters, edginess or crash.* Note: Each full serving (2 scoops) of Ape Sh*t Cutz supplies a total of 300mg caffeine from green tea. Garcinia Cambogia Garcinia cambogia is a small, sour-tasting, pumpkin-shaped fruit that is rich in hydroxycitric acid (HCA).* Research suggests that garcinia cambogia may help decrease oxidative stress, suppress appetite, and support weight loss efforts.*[18,19,20] Dandelion Extract Dandelion is a commonly used all-natural diuretic included to help shed unwanted water weight that tends to accumulate in the body. Research has shown that dandelion may increase urine output, as well as the frequency of urination, for up to 5 hours![9,10]*  Additional studies also suggest dandelion may enhance glucose uptake in skeletal muscle[11], promoting greater utilization and storage of carbohydrates.* Gamma-Butyrobetaine HCl (GBB) Gamma-butyrobetaine (GBB) acts as a carnitine precursor.* It is converted to carnitive via the enzyme Gamma-butyrobetaine dioxygenase (BBD).[12] Gamma-butyrobetaine dioxygenase is an oxidoreductase enzyme that mediates conversion of GBB to carnitine through the movement of electrons.[13]* Why is more carnitine beneficial? Carnitine is the molecule in the body that facilitates transportation of fatty acids into the mitochondria for beta-oxidation, a.k.a. “fat burning”. Greater carnitine availability allows for more fatty acids to be shuttled into the mitochondria to burn as fuel.* Be forewarned that GBB is known to have a prominent thermogenic effect in the body, so expect to feel the heat with Ape Sh*t Cutz!* Yohimbine Bark Extract Yohimbine is a bioactive compound found within the bark of the African tree, Pausinystalia johimbe. It has been noted to function as a powerful CNS stimulant that antagonizes alpha-2-adrenergic receptors in the body, which helps increase energy and focus while also supporting fat burning.*[14] Yohimbine has also been noted to help suppress appetite, helping individuals combat those notorious hunger pangs that arise during diets.*[15,16,17]  Disclaimer:  *These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease. References Baguet, A et al.; Journal of Applied Physiology; “Important role of muscle carnosine in rowing performance;” July 2010;” 2005 Roger C. Harris; et al.; “The effect of a supplement containing β-alanine on muscle carnosine synthesis, ventilatory threshold and exercise capacity in Korean cyclists, during 12 weeks combined endurance and weight training“ Hill, CA et al.; Amino Acids; “Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity ;” February 2007 Kendrick IP, et al. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. (2008) Hasselmo ME. The role of acetylcholine in learning and memory. Curr Opin Neurobiol. 2006;16(6):710–715. doi:10.1016/j.conb.2006.09.002 Institute of Medicine (US) Committee on Military Nutrition Research. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington (DC): National Academies Press (US); 2001. 2, Pharmacology of Caffeine. Available from: https://www.ncbi.nlm.nih.gov/books/NBK223808/ Schubert, M. M., Irwin, C., Seay, R. F., Clarke, H. E., Allegro, D., & Desbrow, B. (2017). Caffeine, coffee, and appetite control: a review. International Journal of Food Sciences and Nutrition, 1–12. https://doi.org/10.1080/09637486.2017.1320537 Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A., & Miller, D. S. (1989). Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. The American Journal of Clinical Nutrition, 49(1), 44–50. https://doi.org/10.1093/ajcn/49.1.44 Rácz-Kotilla E, Rácz G, Solomon A; The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals . Planta Med. (1974) Clare BA, Conroy RS, Spelman K. The Diuretic Effect in Human Subjects of an Extract of Taraxacum officinale Folium over a Single Day. Journal of Alternative and Complementary Medicine. 2009;15(8):929-934. doi:10.1089/acm.2008.0152. Higuchi N1, et al; Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease . Exp Ther Med. (2011) Strijbis K, Vaz F, Distel B; “Enzymology of the carnitine biosynthesis pathway”; IUBMB Life; 2010 May; 62(5):357-62;  Paul HS, Sekas G, Adibi SA (Feb 1992). “Carnitine biosynthesis in hepatic peroxisomes. Demonstration of gamma-butyrobetaine hydroxylase activity”. European Journal of Biochemistry / FEBS. 203 (3): 599–605. doi:10.1111/j.1432-1033.1992.tb16589.x. PMID 1735445 Murburg, M. M., Villacres, E. C., Ko, G. N., & Veith, R. C. (1991). Effects of yohimbine on human sympathetic nervous system function. The Journal of Clinical Endocrinology and Metabolism, 73(4), 861–865. https://doi.org/10.1210/jcem-73-4-861 Mizuki Y, et al; Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety . Prog Neuropsychopharmacol Biol Psychiatry. (1996) Galitzky J, et al; Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers . Eur J Clin Invest. (1988) Callahan MF, Beales M, Oltmans GA; Yohimbine and rauwolscine reduce food intake of genetically obese (obob) and lean mice . Pharmacol Biochem Behav. (1984) Onakpoya I, Hung SK, Perry R, Wider B, Ernst E. The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials. J Obes. 2011;2011:509038. doi:10.1155/2011/509038 Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem. 2002;238(1-2):89-103. doi:10.1023/a:1019911205672 Sripradha R, Sridhar MG, Maithilikarpagaselvi N. Antihyperlipidemic and antioxidant activities of the ethanolic extract of Garcinia cambogia on high fat diet-fed rats. J Complement Integr Med. 2016;13(1):9-16. doi:10.1515/jcim-2015-0020
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VASOGORGE BLACK PRE WORKOUT - Primeval Labs
VASOGORGE BLACK
$39.99
What is Vasogorge Black? Vasogorge Black is a stimulant-free, pump pre workout supplement formulated to promote vasodilation, encourage blood flow, and enhance cellular swelling.*   Vasogorge Black was designed to be a versatile, standalone or stackable pre workout supplement to enhance pumps, increase blood flow, boost energy, and promote endurance.*   The ingredients in Vasogorge Black supported increased cell volume and promote hyperhydration, allowing athletes to sustain a high level of performance even during the most intense workouts.* Can I Stack Vasogorge Black? Vasogorge Black contains no stimulants. As such, it can be used as a standalone pre workout or stacked with your favorite stimulant-based pre workout, such as Primeval Labs Ape Sh*t or Ape Sh*t Cutz.* Ingredients HydroMax (1,500mg) HydroMax is a premium-grade, shelf-stable glycerol supplement containing 65% pure glycerol by weight.*   Previous forms of glycerol contained at most 25% glycerol by mass, which left you with very little glycerol and a lot of unwanted saturated fat. These previous glycerol options also were notorious for clumping due to glycerol’s hygroscopic nature. More likely than not, you yourself were the victim of a clumpy tub of pre workout that you had to throw away in the garbage.*   HydroMax touts improved stability, solubility, and shelf-life compared to glycerol supplements of years past. And, you’re also getting more glycerol on a gram-per-gram basis than with previous versions, too.*   That’s great and all, but what does HydroMax actually do?   HydroMax supports hydration and nutrient absorption due to its ability to enhance muscle cells’ ability to absorb water. In other words, HydroMax helps skeletal muscle cells act like ultra-absorbent sponges encouraging them to soak up extra water and nutrients, improving hydration, stamina, and resistance to fatigue.*   As an added bonus, due to the cell-saturating qualities of HydroMax, it also increases muscle fullness (“water-based” pumps).* VasoDrive-AP™ (254mg) VasoDrive-AP (AmealPeptide®) is a proprietary ingredient derived from casein (yes, the same stuff used in protein powders!) included to promote enhanced blood flow and nutrient delivery.*   VasoDrive-AP contains a combination of two tripeptides naturally occurring in casein in:   Valyl-Prolyl-Proline (VPP), and Isoleucyl-Prolyl-Proline(IPP).   Studies using these two lactotripeptides have demonstrated their ability to support endothelial function and reduce blood pressure by inhibiting angiotensin converting enzyme (ACE) -- an enzyme that causes blood vessels to constrict.[1,2,3,4] *   A 2015 meta-analysis of randomized control trials also found that these same casein-derived lactotripeptides can help reduce both systolic and diastolic blood pressure and promotes arterial elasticity.[3]*   Additionally, inhibiting ACE and/or blocking the angiotensin II receptor has been shown in research to lead to improvements in insulin sensitivity.*   This is noteworthy because researchers have observed a link between insulin resistance and endothelial dysfunction, characterized by reduced nitric oxide, which subsequently limits blood flow to skeletal muscles and decreases muscle pumps.[5,6]*   VasoDrive-AP promotes greater blood flow to skeletal muscles, encouraging greater nutrient delivery and helping deliver better performance and stronger muscle pumps.* Dosing Consume one serving (i.e. 5 capsules) 20-30 minutes prior to training.   Disclaimer: *These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.     References FitzGerald RJ, Meisel H. Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Br J Nutr. 2000;84 Suppl 1:S33-37. Hirota T, Ohki K, Kawagishi R, et al. Casein hydrolysate containing the antihypertensive tripeptides Val-Pro-Pro and Ile-Pro-Pro improves vascular endothelial function independent of blood pressure-lowering effects: contribution of the inhibitory action of angiotensin-converting enzyme. Hypertension research : official journal of the Japanese Society of Hypertension. 2007;30(6):489-496. Fekete ÁA, Givens DI, Lovegrove JA. Casein-Derived Lactotripeptides Reduce Systolic and Diastolic Blood Pressure in a Meta-Analysis of Randomised Clinical Trials. Nutrients. 2015;7(1):659-681. Jäkälä P, Vapaatalo H. Antihypertensive Peptides from Milk Proteins. Pharmaceuticals (Basel). 2010;3(1):251–272. Published 2010 Jan 19. doi:10.3390/ph3010251 Baron AD, Brechtel-Hook G, Johnson A, Hardin D. Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure. Hypertension. 1993;21(2):129-135. Mather KJ, Steinberg HO, Baron AD. Insulin resistance in the vasculature. J Clin Invest.123(3):1003-1004.  
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Creatine CREATINE - Primeval Labs
Creatine
$24.99
What can be said about creatine that hasn’t already been said a thousand times over? It is the single most successful, consistently proven effective bodybuilding supplement in history. Creatine monohydrate has been extensively researched in both young and old individuals, and shown to not only be beneficial but more importantly, safe.[1,2]* Various studies have shown that creatine monohydrate may improve[2,3,4,5,6,7,8,9,10]*: Lean mass gains* Energy production* Power* Strength* Hydration & thermoregulation* Resistance to fatigue* Post-exercise recovery* Working memory & intelligence* Due to the laundry list of benefits creatine supplementation has been noted to offer, we can think of no better single ingredient to usher in the Primeval Labs Commodity Series of products than Creatine Monohydrate!* Primeval Labs Creatine supplies 5 grams of pure creatine monohydrate (the most well-studied form of creatine) per serving.* How Does Creatine Work? When you ingest creatine either from food or dietary supplements, it binds to a phosphate molecule to form creatine phosphate.* As you probably know, ATP (adenosine triphosphate) is the body's primary energy source, and our bodies create ATP from the oxidation (“burning”) of carbohydrates, protein, and fat we obtain from our diet.* So, how do we get energy from ATP? Hydrolysis is a chemical process resulting in the breakdown of a compound due to reaction with water. When ATP is hydrolyzed (reacted with water) one of the high-energy phospho-anhydride bonds in ATP is broken, giving off a considerable amount of thermal energy which can then be used to perform work, such as contracting a muscle to lift a weight.* After ATP is hydrolyzed, it now becomes ADP (adenosine diphosphate), since it has lost one of its phosphate groups.[11]*   From an energy-yielding standpoint, ADP is fairly useless, that is until it regains a phosphate group and becomes ATP once again.* Now, here’s where the magic of creatine comes in.* Our muscles store creatine as creatine-phosphate (phospho-creatine). During the first few moments of intense exercise, our muscles rely on the phosphagen energy system, which consists of ATP stores and phosphocreatine stores.*   While this energy system excels at helping us perform powerfully explosive movements, it can only fuel top end performance for a brief amount of time (~10 seconds). Once your ATP stores are exhausted, your body switches over to oxidizing carbohydrates and fats to regenerate ATP.* However, with greater creatine phosphate stores (like those obtained from supplementing with creatine monohydrate), the body’s ability to more rapidly regenerate ATP is enhanced, allowing you to maintain a higher level of performance for greater periods of time. This allows muscles to increase their total workout output before succumbing to fatigue.*   Essentially, the main mechanism by which creatine enhances performance is through enhancing energy production.*   But that’s not all. Creatine also enhances cellular hydration due to its osmotic properties. This encourages muscle cells to absorb and hold onto extra water.*   Improved cellular hydration promotes greater stamina, and it also has been noted to increase protein synthesis (which supports muscle growth).[12]*   Plus, when muscles are well-hydrated, they look bigger, fuller, and more pumped!* What Can I Stack Creatine With? Primeval Labs Creatine is stimulant-free and can be used in conjunction with any other Primeval Labs supplements.* Do I Need to Cycle Creatine? No.* Creatine is non-hormonal and does not need to be cycled.* When Should I Take Creatine? Creatine can be taken any time of day as its energy-boosting effects are the result of your muscles becoming saturated with creatine. That being said, we are fans of taking it post-workout as both insulin sensitivity and nutrient uptake by muscle cells is greater following exercise.* Disclaimer: *These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.