What can be said about creatine that hasn’t already been said a thousand times over? It is the single most successful, consistently proven effective bodybuilding supplement in history. Creatine monohydrate has been extensively researched in both young and old individuals, and shown to not only be beneficial but more importantly, safe.[1,2]* Various studies have shown that creatine monohydrate may improve[2,3,4,5,6,7,8,9,10]*: Lean mass gains* Energy production* Power* Strength* Hydration & thermoregulation* Resistance to fatigue* Post-exercise recovery* Working memory & intelligence* Due to the laundry list of benefits creatine supplementation has been noted to offer, we can think of no better single ingredient to usher in the Primeval Labs Commodity Series of products than Creatine Monohydrate!* Primeval Labs Creatine supplies 5 grams of pure creatine monohydrate (the most well-studied form of creatine) per serving.* How Does Creatine Work? When you ingest creatine either from food or dietary supplements, it binds to a phosphate molecule to form creatine phosphate.* As you probably know, ATP (adenosine triphosphate) is the body's primary energy source, and our bodies create ATP from the oxidation (“burning”) of carbohydrates, protein, and fat we obtain from our diet.* So, how do we get energy from ATP? Hydrolysis is a chemical process resulting in the breakdown of a compound due to reaction with water. When ATP is hydrolyzed (reacted with water) one of the high-energy phospho-anhydride bonds in ATP is broken, giving off a considerable amount of thermal energy which can then be used to perform work, such as contracting a muscle to lift a weight.* After ATP is hydrolyzed, it now becomes ADP (adenosine diphosphate), since it has lost one of its phosphate groups.* From an energy-yielding standpoint, ADP is fairly useless, that is until it regains a phosphate group and becomes ATP once again.* Now, here’s where the magic of creatine comes in.* Our muscles store creatine as creatine-phosphate (phospho-creatine). During the first few moments of intense exercise, our muscles rely on the phosphagen energy system, which consists of ATP stores and phosphocreatine stores.* While this energy system excels at helping us perform powerfully explosive movements, it can only fuel top end performance for a brief amount of time (~10 seconds). Once your ATP stores are exhausted, your body switches over to oxidizing carbohydrates and fats to regenerate ATP.* However, with greater creatine phosphate stores (like those obtained from supplementing with creatine monohydrate), the body’s ability to more rapidly regenerate ATP is enhanced, allowing you to maintain a higher level of performance for greater periods of time. This allows muscles to increase their total workout output before succumbing to fatigue.* Essentially, the main mechanism by which creatine enhances performance is through enhancing energy production.* But that’s not all. Creatine also enhances cellular hydration due to its osmotic properties. This encourages muscle cells to absorb and hold onto extra water.* Improved cellular hydration promotes greater stamina, and it also has been noted to increase protein synthesis (which supports muscle growth).* Plus, when muscles are well-hydrated, they look bigger, fuller, and more pumped!* What Can I Stack Creatine With? Primeval Labs Creatine is stimulant-free and can be used in conjunction with any other Primeval Labs supplements.* Do I Need to Cycle Creatine? No.* Creatine is non-hormonal and does not need to be cycled.* When Should I Take Creatine? Creatine can be taken any time of day as its energy-boosting effects are the result of your muscles becoming saturated with creatine. That being said, we are fans of taking it post-workout as both insulin sensitivity and nutrient uptake by muscle cells is greater following exercise.* Disclaimer: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Ape Sh*t Cutz$34.99
What is Ape Sh*t Cutz? Ape Sh*t Cutz is a thermogenic pre workout scientifically formulated to support increased athletic performance, endurance, and calorie burning. We’ve taken the best elements from our best-selling, high energy pre workout Ape Sh*t and added in prominent weight loss support agents to create the ultimate fat-burning pre workout supplement.* What’s the Difference Between Ape Sh*t & Ape Sh*t Cutz? The biggest difference between the original Ape Sh*t pre workout and Ape Sh*t Cutz is the swap of nitric oxide support ingredients for weight loss support agents. In lieu of L-Citrulline, Agmatine, and Taurine, we’ve included several compounds that help support fat metabolism and increased thermogenesis to help burn more calories during training.* Make no mistake though, Ape Sh*t Cutz still offers the same delicious flavor you’ve come to expect from all Primeval Labs supplements. In fact, we believe this may surpass the flavoring of the original Ape Sh*t!* Ape Sh*t Cutz Ingredients Beta Alanine Beta alanine is a prominent endurance support supplement known to support stamina and resistance to fatigue. It does so by increasing concentrations of a powerful intracellular buffer known as carnosine.* With higher levels of carnosine, skeletal muscle is better able to buffer acidic (H+) ions that accumulate during repeated muscle contractions. This enables muscles to last longer before succumbing to fatigue, promoting greater stamina, strength, and endurance.*[2,3,4] Choline Bitartrate Choline is an essential nutrient that plays a key role in cognitive development, muscle movement, and the structure of cell membranes. It also serves as a building block for the “learning transmitter”, acetylcholine, which is well-known to impact focus, learning, memory, and the “mind-muscle connection.”* Supplementing with choline helps support acetylcholine production in the body promoting greater focus and a stronger mind-muscle connection during training.* Caffeine Caffeine is great for increasing mental energy, focus, and concentration. It’s also useful for supporting weight loss due to the facts that caffeine has been noted in various research trials[5,6,7,8] to help*: Enhance fatty acid oxidation* Increase lipolysis via cyclic AMP* Boost metabolic rate* Suppresse appetite This consummate pre workout stimulant also helps improve exercise performance by reducing perceived exertion, which may help athletes to train longer, banging out more reps and burning more calories.* Ape Sh*t Cutz utilizes natural caffeine from green tea to supply smooth, long-lasting energy without the jitters, edginess or crash.* Note: Each full serving (2 scoops) of Ape Sh*t Cutz supplies a total of 300mg caffeine from green tea. Garcinia Cambogia Garcinia cambogia is a small, sour-tasting, pumpkin-shaped fruit that is rich in hydroxycitric acid (HCA).* Research suggests that garcinia cambogia may help decrease oxidative stress, suppress appetite, and support weight loss efforts.*[18,19,20] Dandelion Extract Dandelion is a commonly used all-natural diuretic included to help shed unwanted water weight that tends to accumulate in the body. Research has shown that dandelion may increase urine output, as well as the frequency of urination, for up to 5 hours![9,10]* Additional studies also suggest dandelion may enhance glucose uptake in skeletal muscle, promoting greater utilization and storage of carbohydrates.* Gamma-Butyrobetaine HCl (GBB) Gamma-butyrobetaine (GBB) acts as a carnitine precursor.* It is converted to carnitive via the enzyme Gamma-butyrobetaine dioxygenase (BBD). Gamma-butyrobetaine dioxygenase is an oxidoreductase enzyme that mediates conversion of GBB to carnitine through the movement of electrons.* Why is more carnitine beneficial? Carnitine is the molecule in the body that facilitates transportation of fatty acids into the mitochondria for beta-oxidation, a.k.a. “fat burning”. Greater carnitine availability allows for more fatty acids to be shuttled into the mitochondria to burn as fuel.* Be forewarned that GBB is known to have a prominent thermogenic effect in the body, so expect to feel the heat with Ape Sh*t Cutz!* Yohimbine Bark Extract Yohimbine is a bioactive compound found within the bark of the African tree, Pausinystalia johimbe. It has been noted to function as a powerful CNS stimulant that antagonizes alpha-2-adrenergic receptors in the body, which helps increase energy and focus while also supporting fat burning.* Yohimbine has also been noted to help suppress appetite, helping individuals combat those notorious hunger pangs that arise during diets.*[15,16,17] Disclaimer: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References Baguet, A et al.; Journal of Applied Physiology; “Important role of muscle carnosine in rowing performance;” July 2010;” 2005 Roger C. Harris; et al.; “The effect of a supplement containing β-alanine on muscle carnosine synthesis, ventilatory threshold and exercise capacity in Korean cyclists, during 12 weeks combined endurance and weight training“ Hill, CA et al.; Amino Acids; “Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity ;” February 2007 Kendrick IP, et al. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. (2008) Hasselmo ME. The role of acetylcholine in learning and memory. Curr Opin Neurobiol. 2006;16(6):710–715. doi:10.1016/j.conb.2006.09.002 Institute of Medicine (US) Committee on Military Nutrition Research. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington (DC): National Academies Press (US); 2001. 2, Pharmacology of Caffeine. Available from: https://www.ncbi.nlm.nih.gov/books/NBK223808/ Schubert, M. M., Irwin, C., Seay, R. F., Clarke, H. E., Allegro, D., & Desbrow, B. (2017). Caffeine, coffee, and appetite control: a review. International Journal of Food Sciences and Nutrition, 1–12. https://doi.org/10.1080/09637486.2017.1320537 Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A., & Miller, D. S. (1989). Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. The American Journal of Clinical Nutrition, 49(1), 44–50. https://doi.org/10.1093/ajcn/49.1.44 Rácz-Kotilla E, Rácz G, Solomon A; The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals . Planta Med. (1974) Clare BA, Conroy RS, Spelman K. The Diuretic Effect in Human Subjects of an Extract of Taraxacum officinale Folium over a Single Day. Journal of Alternative and Complementary Medicine. 2009;15(8):929-934. doi:10.1089/acm.2008.0152. Higuchi N1, et al; Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease . Exp Ther Med. (2011) Strijbis K, Vaz F, Distel B; “Enzymology of the carnitine biosynthesis pathway”; IUBMB Life; 2010 May; 62(5):357-62; Paul HS, Sekas G, Adibi SA (Feb 1992). “Carnitine biosynthesis in hepatic peroxisomes. Demonstration of gamma-butyrobetaine hydroxylase activity”. European Journal of Biochemistry / FEBS. 203 (3): 599–605. doi:10.1111/j.1432-1033.1992.tb16589.x. PMID 1735445 Murburg, M. M., Villacres, E. C., Ko, G. N., & Veith, R. C. (1991). Effects of yohimbine on human sympathetic nervous system function. The Journal of Clinical Endocrinology and Metabolism, 73(4), 861–865. https://doi.org/10.1210/jcem-73-4-861 Mizuki Y, et al; Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety . Prog Neuropsychopharmacol Biol Psychiatry. (1996) Galitzky J, et al; Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers . Eur J Clin Invest. (1988) Callahan MF, Beales M, Oltmans GA; Yohimbine and rauwolscine reduce food intake of genetically obese (obob) and lean mice . Pharmacol Biochem Behav. (1984) Onakpoya I, Hung SK, Perry R, Wider B, Ernst E. The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials. J Obes. 2011;2011:509038. doi:10.1155/2011/509038 Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem. 2002;238(1-2):89-103. doi:10.1023/a:1019911205672 Sripradha R, Sridhar MG, Maithilikarpagaselvi N. Antihyperlipidemic and antioxidant activities of the ethanolic extract of Garcinia cambogia on high fat diet-fed rats. J Complement Integr Med. 2016;13(1):9-16. doi:10.1515/jcim-2015-0020
What is Vasogorge Black? Vasogorge Black is a stimulant-free, pump pre workout supplement formulated to promote vasodilation, encourage blood flow, and enhance cellular swelling.* Vasogorge Black was designed to be a versatile, standalone or stackable pre workout supplement to enhance pumps, increase blood flow, boost energy, and promote endurance.* The ingredients in Vasogorge Black supported increased cell volume and promote hyperhydration, allowing athletes to sustain a high level of performance even during the most intense workouts.* Can I Stack Vasogorge Black? Vasogorge Black contains no stimulants. As such, it can be used as a standalone pre workout or stacked with your favorite stimulant-based pre workout, such as Primeval Labs Ape Sh*t or Ape Sh*t Cutz.* Ingredients HydroMax (1,500mg) HydroMax is a premium-grade, shelf-stable glycerol supplement containing 65% pure glycerol by weight.* Previous forms of glycerol contained at most 25% glycerol by mass, which left you with very little glycerol and a lot of unwanted saturated fat. These previous glycerol options also were notorious for clumping due to glycerol’s hygroscopic nature. More likely than not, you yourself were the victim of a clumpy tub of pre workout that you had to throw away in the garbage.* HydroMax touts improved stability, solubility, and shelf-life compared to glycerol supplements of years past. And, you’re also getting more glycerol on a gram-per-gram basis than with previous versions, too.* That’s great and all, but what does HydroMax actually do? HydroMax supports hydration and nutrient absorption due to its ability to enhance muscle cells’ ability to absorb water. In other words, HydroMax helps skeletal muscle cells act like ultra-absorbent sponges encouraging them to soak up extra water and nutrients, improving hydration, stamina, and resistance to fatigue.* As an added bonus, due to the cell-saturating qualities of HydroMax, it also increases muscle fullness (“water-based” pumps).* VasoDrive-AP™ (254mg) VasoDrive-AP (AmealPeptide®) is a proprietary ingredient derived from casein (yes, the same stuff used in protein powders!) included to promote enhanced blood flow and nutrient delivery.* VasoDrive-AP contains a combination of two tripeptides naturally occurring in casein in: Valyl-Prolyl-Proline (VPP), and Isoleucyl-Prolyl-Proline(IPP). Studies using these two lactotripeptides have demonstrated their ability to support endothelial function and reduce blood pressure by inhibiting angiotensin converting enzyme (ACE) -- an enzyme that causes blood vessels to constrict.[1,2,3,4] * A 2015 meta-analysis of randomized control trials also found that these same casein-derived lactotripeptides can help reduce both systolic and diastolic blood pressure and promotes arterial elasticity.* Additionally, inhibiting ACE and/or blocking the angiotensin II receptor has been shown in research to lead to improvements in insulin sensitivity.* This is noteworthy because researchers have observed a link between insulin resistance and endothelial dysfunction, characterized by reduced nitric oxide, which subsequently limits blood flow to skeletal muscles and decreases muscle pumps.[5,6]* VasoDrive-AP promotes greater blood flow to skeletal muscles, encouraging greater nutrient delivery and helping deliver better performance and stronger muscle pumps.* Dosing Consume one serving (i.e. 5 capsules) 20-30 minutes prior to training. Disclaimer: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References FitzGerald RJ, Meisel H. Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Br J Nutr. 2000;84 Suppl 1:S33-37. Hirota T, Ohki K, Kawagishi R, et al. Casein hydrolysate containing the antihypertensive tripeptides Val-Pro-Pro and Ile-Pro-Pro improves vascular endothelial function independent of blood pressure-lowering effects: contribution of the inhibitory action of angiotensin-converting enzyme. Hypertension research : official journal of the Japanese Society of Hypertension. 2007;30(6):489-496. Fekete ÁA, Givens DI, Lovegrove JA. Casein-Derived Lactotripeptides Reduce Systolic and Diastolic Blood Pressure in a Meta-Analysis of Randomised Clinical Trials. Nutrients. 2015;7(1):659-681. Jäkälä P, Vapaatalo H. Antihypertensive Peptides from Milk Proteins. Pharmaceuticals (Basel). 2010;3(1):251–272. Published 2010 Jan 19. doi:10.3390/ph3010251 Baron AD, Brechtel-Hook G, Johnson A, Hardin D. Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure. Hypertension. 1993;21(2):129-135. Mather KJ, Steinberg HO, Baron AD. Insulin resistance in the vasculature. J Clin Invest.123(3):1003-1004.
Primeval Labs WHEY$59.99
Protein powder is one of the most popular supplements on the market. In fact, it’s one of the first supplements an individual purchases when they embark on their fitness journey.* The reason for this is that consuming sufficient dietary protein is key to achieving just about any performance or physique goal, be it muscle growth, fat loss, body recomposition, or kicking the opponent’s tail on the field of competition.[1,2,3,4] * Recognizing the demand for not only a premium-quality protein powder, but also one that was delicious and affordable, resulted in the creation of Primeval Labs WHEY.* What is WHEY? WHEY is a 100% pure whey protein concentrate (WPC) protein powder that mixes easily and tastes absolutely delicious.* Our whey protein concentrate is derived from high-quality milk, creating a protein that is both highly bioavailable and naturally rich in branched-chain amino acids (BCAAs).* This makes WHEY an ideal protein supplement for any active individual looking to support the performance, health, and physique goals.* Key Features of WHEY 23 grams protein per serving WHEY uses ONLY 100% WPC-80 Available in three mouth-watering flavors Mixes easily* Supports muscle recovery and growth* Supports weight loss* Naturally rich in BCAAs* Added digestive enzymes* More About Whey Protein Concentrate Whey protein is one of two proteins naturally occurring in cow’s milk.* It accounts for 20% of the total protein in milk, with casein accounting for the remaining 80%.* Whey protein is considered to be one of the best forms of protein due to is high biological value (BV), rivaling that of egg protein -- nature’s “perfect” protein. * In fact, whey has a biological value of 104 -- that’s higher than egg, beef, chicken, or fish protein.[5,6]* Basically, what this means is that whey protein is efficiently digested, absorbed, and used by the human body. * Other proteins that have low biological values (such as most plant proteins) are not efficiently used by the body, which means a higher amount of them needs to be consumed in order to deliver quality amounts of essential amino acids.* Since whey protein has a very high biological value it is ideally suited for individuals looking to support muscle growth, fat loss, recovery, and performance.* Furthermore, whey protein is rapidly digested, making it an enticing option for a post workout recovery shake.* Research also supports the use of whey protein supplementation when trying to build muscle, lose fat, and improve body composition.*[7,8] Additional studies also find that supplementing with whey protein may enhance anaerobic power and strength compared to supplementing with carbohydrates, due to improved recovery when supplementing with protein.* WHEY Uses Only WPC-80 A little known fact about whey protein concentrate is that its protein contents can vary between 34-80%!* Further complicating the matter is the fact that companies are NOT required to list which grade of whey protein concentrate is included in their protein powder, which means you could be getting (paying for) as little as 34% protein by weight in your powder.* What makes up the remaining percentage?* A mixture of carbohydrates (lactose) and fat.* Together this means that not only is your “protein” powder high in fat and lactose (which is sure to lead to GI upset), but it’s also low in protein.* We don’t know about you, but we hardly consider that a “protein powder”.* That’s why we use only the highest-quality whey protein concentrate in our WHEY protein powder -- WPC-80.* This delivers a powder that is high in protein while keeping carbs, fat, and total calories in check.* The other added benefit of using a concentrate as opposed to something like hydrolyzed whey protein is that it retains higher amounts of the bioactive fractions naturally occurring in whey, such as: ß-lactoglobulin α-lactalbumin Bovine serum albumin Immunoglobulins Glycomacropeptide Lactoferrin Lactoperoxidase And, whey concentrate also offers a superior texture and mouthfeel compared to other protein powders which can either taste thin and watery or gritty and grass-like.* Added Digestive Support WPC-80 is naturally low in lactose and whey in and of itself if highly bioavailable, but we sought to improve its digestion and uptake even more with the addition of DigeSEB™.* DigeSEB™ is a unique complex of digestive enzymes included to enhance digestibility, decrease bloating, and boost the overall nutrition of WHEY.* DigeSEB™ contains a special combination of FIVE digestive enzymes to improve digestibility of a broad range of foods (including dairy) into nutrients that the body can efficiently use.* Enzymes included in DigeSEB™ are: Amylases - naturally occurring enzyme that breaks down carbohydrates, more specifically starch, into smaller dextrins and sugars Lactase - digestive enzyme that breaks down lactose (milk sugar) Proteases - enzymes that hydrolyze (breaks down) proteins found in whey, casein, steak, chicken, fish as well as plant proteins into smaller chains of polypeptides and amino acids for uptake and utilization by the body Lipase - enzyme that catalyzes the breakdown of fats into essential fatty acids used by the body for cell membrane repair and maintenance, hormone production, and numerous other functions Cellulase - enzyme that digests cellulose, a complex carbohydrate found in all plant material including plant fiber Disclaimer: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References Rodriguez, N. R., Di Marco, N. M., & Langley, S. (2009). American College of Sports Medicine position stand. Nutrition and athletic performance. Medicine and Science in Sports and Exercise, 41(3), 709–731. https://doi.org/10.1249/MSS.0b013e31890eb86 Carbone JW, Pasiakos SM. Dietary Protein and Muscle Mass: Translating Science to Application and Health Benefit. Nutrients. 2019;11(5):1136. Published 2019 May 22. doi:10.3390/nu11051136 Iraki J, Fitschen P, Espinar S, Helms E. Nutrition Recommendations for Bodybuilders in the Off-Season: A Narrative Review. Sports (Basel). 2019;7(7):154. Published 2019 Jun 26. doi:10.3390/sports7070154 Roberts, B. M., Helms, E. R., Trexler, E. T., & Fitschen, P. J. (2020). Nutritional Recommendations for Physique Athletes, 71(January), 79–108. https://doi.org/10.2478/hukin-2019-0096 Hoffman JR, Falvo MJ. Protein - Which is Best?. J Sports Sci Med. 2004;3(3):118–130. Published 2004 Sep 1. Moore DR, Soeters PB. The Biological Value of Protein. Nestle Nutr Inst Workshop Ser. 2015;82:39-51. doi:10.1159/000382000 Miller PE, Alexander DD, Perez V. Effects of whey protein and resistance exercise on body composition: a meta-analysis of randomized controlled trials. J Am Coll Nutr. 2014;33(2):163-175. doi:10.1080/07315724.2013.875365. Bell KE, Snijders T, Zulyniak M, et al. A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial. Fisher G, ed. PLoS ONE. 2017;12(7):e0181387. doi:10.1371/journal.pone.0181387. West DWD, Abou Sawan S, Mazzulla M, Williamson E, Moore DR. Whey protein supplementation enhances whole body protein metabolism and performance recovery after resistance exercise: a double-blind crossover study. Nutrients (2017) 9:735. 10.3390/nu907073 REFERENCE MANUAL FOR U . S . WHEY AND LACTOSE PRODUCTS. (n.d.).
DAY2DAY Fruits & Greens$34.99
We all know that a core principle of wellness is a healthy diet, rich in whole foods like fruits, vegetables, whole grains, lean proteins, and healthy fats.* At the same time, we all have those days when our intake of those healthy foods is a bit short.* Plus, hard training increases nutritional requirements as intense exercise depletes mineral stores and increases oxidative stress.* In these situations, it’s necessary to consume sufficient amounts of essential vitamins and minerals as well as antioxidants and polyphenols.* That’s why we set out to develop a greens supplement that not only helps support your day-to-day general nutritional requirements, but also one that offers benefits to individuals living an active lifestyle.* This resulted in the creation of Day2Day. What is Day2Day? Day2Day is a great-tasting nutritional support supplement delivering 5 grams combined powdered fruits and vegetables.* Greens Blend (2.5g) For our greens blend, we chose an extensive array of nutritional powerhouses, such as broccoli, spinach, kale, and alfalfa.* Our greens blend also contains both chlorella and spirulina for their rich phytochemical content.* Chlorella, for instance, is packed with chlorophyll, a green pigment that plants use (along with light) to make food.* Animal studies indicate that chlorella may support detoxification by helping to remove heavy metals and other harmful compounds from the body.*[1,2] Fruits Blend (2.5g) Our fruits blend contains a diverse lineup of nutritious fruit powders*, including: Pineapple juice Coconut water Strawberry juice Lemon juice Collectively, this assembly of fruits and greens makes Day2Day an ideal supplement for any active individual looking to support energy, immune function, recovery, and performance.* Key Features of Day2Day 5 grams combined fruits and vegetables* Added digestive enzymes* Refreshing taste* Easy-to-mix* Do I Still Need to Eat My Vegetables? Absolutely! Fruits and vegetables are rich in essential vitamins and minerals as well as fiber and countless other antioxidants and polyphenols that the body needs to function optimally on a day-to-day basis.* Day2Day is NOT meant to replace your daily intake of fruits or vegetables. It’s there to complement or supplement your intakes.* Added Digestive Support For added digestive support, Day2Day also includes a comprehensive blend of digestive enzymes in DigeSEB™.* DigeSEB™ is a unique complex of digestive enzymes included to enhance digestibility, decrease bloating, and boost overall nutrition.* DigeSEB™ contains a special combination of FIVE digestive enzymes to improve digestibility of a broad range of foods (including dairy) into nutrients that the body can efficiently use.* Enzymes included in DigeSEB™ are: Amylases - naturally occurring enzyme that breaks down carbohydrates, more specifically starch, into smaller dextrins and sugars Lactase - digestive enzyme that breaks down lactose (milk sugar) Proteases - enzymes that hydrolyze (breaks down) proteins found in whey, casein, steak, chicken, fish as well as plant proteins into smaller chains of polypeptides and amino acids for uptake and utilization by the body Lipase - enzyme that catalyzes the breakdown of fats into essential fatty acids used by the body for cell membrane repair and maintenance, hormone production, and numerous other functions Cellulase - enzyme that digests cellulose, a complex carbohydrate found in all plant material including plant fiber Disclaimer: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References Sears ME. Chelation: harnessing and enhancing heavy metal detoxification--a review. ScientificWorldJournal. 2013;2013:219840. Published 2013 Apr 18. doi:10.1155/2013/219840 Uchikawa, T., Kumamoto, Y., Maruyama, I., Kumamoto, S., Ando, Y., & Yasutake, A. (2011, January). Enhanced elimination of tissue methylmercury in Parachlorella beijerinckii-fed mice. The Journal of Toxicological Sciences. Japan. https://doi.org/10.2131/jts.36.121
Pyretic X is a well-rounded thermogenic weight loss supplement formulated to help support increased thermogenesis, greater energy expenditure, and reduced body fat.* When combined with a reduced-calorie diet and exercise program, the ingredients in Pyretic X may help support dietary compliance and calorie burning, thereby promoting more efficient weight loss and better performance in the gym.* Pyretic X Ingredients Olive Leaf Extract (20% Oleuropein) Olive leaf extract is rich in numerous bioactive compounds, the most well-known of which is oleuropein.* Oleuropein is a versatile compound that has been noted in scientific research to possess a wide range of activities, including*: Antioxidant Anti-inflammatory Anti-atherogenic Antimicrobial activity Antiviral activity Hypolipidemic hypoglycemic effect Oleuropein also stimulates BAT (brown adipose tissue), inhibits PPAR-γ receptor, and suppresses the proliferation of adipocytes (fat cells).* Oleuropein also enhances thermogenesis by increasing uncoupling protein-1 (UCP1).* Additional research indicates that olive leaf extract supplementation may support better insulin sensitivity and help limit oxidation of LDL (“bad”) cholesterol.* Animal studies also indicate that olive leaf extract supports thyroid function.* As you’re probably aware, the thyroid gland is critical to proper functioning of the metabolism.* Green Coffee Extract Green coffee beans are raw, unroasted coffee beans. They are rich in many pharmacologically active compounds, including chlorogenic acid.* Human studies note an inverse association between coffee intake and weight gain.* Green coffee extract may help reduce body weight and fat mass, possibly due to reducing the amount of carbohydrate taken up by the intestines following a meal.* Researchers have theorized that green coffee extract may modify hormone secretion and glucose tolerance in humans.* Green coffee extract’s primary bioactive, chlorogenic acid, appears to increase nitric oxide availability and possess antihypertensive effects.* Research also indicates chlorogenic acid reduces the hyperglycemic peak associated with carbohydrate ingestion. This lowers insulin activity and may help reduce fat accumulation.* Natural Caffeine Caffeine is the well-known central nervous system (CNS) stimulant widely available in foods common to the diet, including coffee, tea, and dark chocolate.* Caffeine is best known for its ability to increase feelings of mental energy, due to its antagonism of adenosine receptors in the brain.* Regarding weight loss support, caffeine has been shown to help to boost metabolism, increase calorie burning, and enhance lipolysis (the “liberating” of stored fatty acids).[10,11]* Caffeine further supports weight loss by acting as a mild appetite suppressant, which may help reduce calorie intake at meal time.* Dieting on low calories is also known to lead to feelings of sluggish, lethargy, and a general lack of motivation to train hard.* Caffeine can help increase energy and motivation due to its ability to stimulate dopamine (“the mood and motivation” molecule) release in the brain, which increases mood, motivation and focus.* Interestingly, dopamine also increases thermogenesis in brown adipose tissue, further increasing calorie burning.* Theobromine Theobromine is a chemical cousin of caffeine and the principal alkaloid in Theobroma cacao (the cacao bean). It’s also found in varying quantities in coffee and dark chocolate.* Theobromine is traditionally used as a bronchodilator and as a vasodilator as well as a diuretic.*[14,15] Research in animals shows that supplementation with a theobromine-rich cocoa powder encourages significant weight loss.* Anecdotally, theobromine supplies a smoother, subtler, longer-lasting energy that complements the fast-acting energy of caffeine. It’s thought that combining the two may help limit the unwanted energy crash that accompanies high doses of caffeine.* This may be due, in part, to theobromine having a longer half-life than caffeine.* Caffeine Anhydrous Pyretic X contains an additional 100mg of fast-acting caffeine anhydrous to further increase feelings of enhanced mental and physical energy to complement the smooth energy of Natural caffeine.* In total, Pyretic X contains 253mg of caffeine per full serving (2 capsules). Yohimbe Bark (8% Yohimbine) Yohimbine (pausinystalia johimbe) is a plant native to western and central Africa.* Extracts from yohimbe have long been used in traditional medicine as an aphrodisiac.* The primary active constituent in yohibe, yohimbine, is a prominent weight loss supplement due to its ability to antagonize (“block”) alpha-adrenergic receptors, thereby supporting fat burning.* “Stubborn” fat areas have higher concentrations of alpha receptors and blocking them encourages increased fat-burning in those areas as greater amounts of fat-burning catecholamines (noradrenaline and adrenaline) can then bind to the beta receptors on fat cells.* Yohimbine has also been explored as a potential ergogenic and body recomposition aid.* Paradoxine® Paradoxine is a research-backed, patented extract of Grains of Paradise (Aframomum Melegueta) standardized to 12.5% 6-paradol.* 6-paradol is an aromatic ketone that is the major bioactive constituent of Grains of Paradise.* Research indicates that supplementation with Grains of Paradise extract may stimulate thermogenesis, increase energy expenditure, and decrease body fat.[18,19,20]* Cayenne Pepper Cayenne pepper contains the fiery alkaloid capsaicin which has been noted to possess some very enticing weight loss benefits.* Capsaicin has been noted in research to help reduce appetite and increase satiety by increasing glucagon-like peptide 1 (GLP-1) and decreasing ghrelin (the hunger hormone).* Additional studies indicate that capsaicin can stimulate brown fat thermogenesis, which supports greater energy expenditure and calorie burning.* Capsaicin may also help reduce appetite and calorie intake, due to its binding and activation of transient receptor potential vanilloid-1 (TRPV1) in the mouth, stomach and small intestine.* Activation of TRPV1 receptor stimulates the release of noradrenaline and dopamine, which have been noted to enhance weight loss and exercise performance.* SUGGESTED USE: Consume 2 capsules daily. To assess tolerance, it is suggested to begin with one capsule per day. Never exceed 4 capsules in any single 24-hour period. Disclaimer: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm. 2010;78(2):133-54. Svobodova M, Andreadou I, Skaltsounis AL, Kopecky J, Flachs P. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014;9(1):376. doi:10.1007/s12263-013-0376-0 Oi-Kano Y, Kawada T, Watanabe T, et al. Oleuropein, a phenolic compound in extra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. J Nutr Sci Vitaminol (Tokyo). 2008;54(5):363-370. doi:10.3177/jnsv.54.363 De Bock M, Derraik JGB, Brennan CM, et al. Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial. Nerurkar PV, ed. PLoS ONE. 2013;8(3):e57622. doi:10.1371/journal.pone.0057622. Al-Qarawi AA, Al-Damegh MA, ElMougy SA Effect of freeze dried extract of Olea europaea on the pituitary-thyroid axis in rats. Phytother Res. (2002) Lopez-Garcia E, Van Dam RM, Rajpathak S, Willett WC, Manson JE, Hu FB. Changes in caffeine intake and long-term weight change in men and women. American Journal of Clinical Nutrition. 2006;83(3):674–680. Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. American Journal of Clinical Nutrition. 2003;78(4):728–733 Wong RH, Garg ML, Wood LG, Howe PR. Antihypertensive potential of combined extracts of olive leaf, green coffee bean and beetroot: a randomized, double-blind, placebo-controlled crossover trial. Nutrients. 2014;6(11):4881-4894. Published 2014 Nov 5. doi:10.3390/nu6114881 Tunnicliffe JM, Eller LK, Reimer RA, Hittel DS, Shearer J. Chlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide response in rats. Appl Physiol Nutr Metab. 2011 Oct;36(5):650-9. Nehlig A. Is caffeine a cognitive enhancer? J Alzheimers Dis 2010;20 Suppl 1, S85-94. Habowski SM, Sandrock J, et al. Lieberman, H. R., Wurtman, R. J., Emde, G. G., Roberts, C., & Coviella, I. L. (1987). The effects of low doses of caffeine on human performance and mood.Psychopharmacology, 92(3), 308–312. Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A., & Miller, D. S. (1989). Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. The American Journal of Clinical Nutrition, 49(1), 44–50. https://doi.org/10.1093/ajcn/49.1.44 Kohlie, R., Perwitz, N., Resch, J., Schmid, S. M., Lehnert, H., Klein, J., & Iwen, K. A. (2017). Dopamine directly increases mitochondrial mass and thermogenesis in brown adipocytes. Journal of Molecular Endocrinology, 58(2), 57–66. https://doi.org/10.1530/JME-16-0159 IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Coffee, Tea, Mate, Methylxanthines and Methylglyoxal. Lyon (FR): International Agency for Research on Cancer; 1991. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 51.) Theobromine. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507032/ Dorfman LJ, Jarvik ME. Comparative stimulant and diuretic actions of caffeine and theobromine in man. Clin Pharmacol Ther. 1970;11(6):869-872. doi:10.1002/cpt1970116869 Eteng, M., Ibekwe, H. A., Umoh, U., Ebong, P., Umoh, I., & Eyong, E. (2007). Theobromine rich cocoa powder induces weight loss and changes in lipid profile of obese Wistar rats. Discovery and Innovation, 18. https://doi.org/10.4314/dai.v18i3.15745 Martínez-Pinilla E, Oñatibia-Astibia A, Franco R. The relevance of theobromine for the beneficial effects of cocoa consumption. Front Pharmacol. 2015;6:30. Published 2015 Feb 20. doi:10.3389/fphar.2015.00030 Iwami M, Mahmoud FA, Shiina T, et al. Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats. Auton Neurosci. 2011;161(1-2):63-67. doi:10.1016/j.autneu.2010.11.012 Sugita, J., Yoneshiro, T., et al; “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738; Sugita J, Yoneshiro T, et al; “Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans”; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27 Smeets AJ and Westerterp-Plantenga MS. The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety. European Journal of Nutrition. 2009;48(4):229-234. doi:10.1007/s00394-009-0006-1. Whiting S, et al. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite 2012;59(2): p.341-8. Ludy MJ, et al. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 2012: 37(2) p. 103-21. Galitzky J, Taouis M, Berlan M, Rivière D, Garrigues M, Lafontan M. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. Eur J Clin Invest. 1988;18(6):587-594. doi:10.1111/j.1365-2362.1988.tb01272.x Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med. 2006;14(4):289-299. doi:10.1080/15438620600987106
What is Electrolyte? Electrolyte is a great-tasting electrolyte matrix formulated to give hard-training athletes a boost before, during, or after training.* Each serving of Electrolyte provides quality doses of essential electrolytes, including: Sodium Potassium Magnesium Phosphorous Calcium Our custom flavoring systems are like none other, making Electrolyte not only a premium-quality hydration support supplement, but one that also tastes delicious and refreshing!* Why Are Electrolytes Important? It takes only a 2% loss of total body water content to start feeling thirsty.* And, once the body reaches this point, it’s already in a state of dehydration.* Signs of dehydration include: Excessive sweating* Thirst* Decreased urine output or darkly colored urine* Headache* Fatigue* Cramping* Dizziness* Difficulty concentrating* Electrolytes are the minerals responsible for shuttling water to the areas in the body that need it most.* Additionally, electrolytes also help maintain optimal fluid balance within cells themselves.* Electrolyte Features Tastes amazing* TWO delicious flavors* 60 servings! NO sugar* ZERO Calories* Premium-quality electrolytes* Vegetarian-friendly* Supports metabolism* Why Choose Electrolyte? By the time you feel symptoms of dehydration, simply drinking plain water does not deliver what the body needs quick enough.* Be it first thing in the morning, at the gym, in the office, or on the road, being even slightly dehydrated can lead to feelings of lethargy and/or brain fog.* In fact, research shows that organ function, cognitive function, and mood can be hindered rather significantly when the body’s total water content drops by as little as 1%.*[1,2] Additional survey data indicates that up to 75% of adults may suffer from dehydration.* Dehydration also becomes a concern when colds and flu strike.* Basically, rapid hydration is important if you: Just finished training intensely* Work outdoors in hot environments* Travel* Are sick* Had one too many* Primeval Labs Electrolytes delivers premium-quality electrolytes from Calci-K and Pink Himalayan salt to support hydration and optimal bodily function.* What Do Electrolytes Do? Sodium The human body requires ~500mg per day of sodium to function properly* Helps regulate blood pressure and blood volume* Helps maintain fluid balance in the body* Required for proper muscle function* Potassium Helps maintain fluid balance inside cells* Essential for optimal muscle function* Supports a regular heartbeat* Serves an important role in neurotransmission* Calcium Essential for strong bones and teeth* 99% of bodily calcium stores reside in bone* Involved in nerve impulse transmission (which tells the muscle to contract), muscle contraction, and blood clotting* Magnesium Involved in more than 300 reactions in the body* fourth most abundant mineral in the body* Required for synthesis of DNA and RNA* Helps regulate nerve and muscle function* Supports immune system function* Helps promote stable blood sugar levels* Phosphorous second most abundant mineral in the body* Works with B-vitamins to support kidney function and muscle contractions Helps maintain a normal heartbeat* Supports ATP production* Disclaimer:*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References1. Kempton MJ, Ettinger U, Foster R, et al. Dehydration affects brain structure and function in healthy adolescents. Hum Brain Mapp. 2011;32(1):71-79. doi:10.1002/hbm.209992. Riebl SK, Davy BM. The Hydration Equation: Update on Water Balance and Cognitive Performance. ACSMs Health Fit J. 2013;17(6):21-28.doi:10.1249/FIT.0b013e3182a9570f3. Survey of 3003 Americans, Nutrition Information Center, New York Hospital-Cornell Medical Center (April 14, 1998).